ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2016
Metabotropic Glutamate Receptor Subtype 7 in the Bed Nucleus of the Stria Terminalis is Essential for Intermale Aggression.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Coordination of social behaviors by the bed nucleus of the stria terminalis.The European journal of neuroscience · 2022Pooled it
- Sex differences in fear responses: Neural circuits.Neuropharmacology · 2023Review
- Visualizing traumatic stress-induced structural plasticity in a medial amygdala pathway using mGRASP.Frontiers in molecular neuroscience · 2023Article
- Anger management: Mechanisms of glutamate receptor-mediated synaptic plasticity underlying animal aggression.The international journal of biochemistry & cell biology · 2022Review
- Aggression Priming by Potentiation of Medial Amygdala Circuits.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- A biochemical mechanism for time-encoding memory formation within individual synapses of Purkinje cells.PloS one · 2021Article
- Metabotropic Glutamate Receptor Subtype 7 Is Essential for Ejaculation.Molecular neurobiology · 2020Article
- Phenotypic profiling of mGluGenes, brain, and behavior · 2020Article
- Ecotype differences in aggression, neural activity and behaviorally relevant gene expression in cichlid fish.Genes, brain, and behavior · 2020Article
- Potentiation of Divergent Medial Amygdala Pathways Drives Experience-Dependent Aggression Escalation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Glutamate in Male and Female Sexual Behavior: Receptors, Transporters, and Steroid Independence.Frontiers in behavioral neuroscience · 2020Review
- The Role of the N-Methyl-D-Aspartate Receptors in Social Behavior in Rodents.International journal of molecular sciences · 2019Review
- The Role of Metabotropic Glutamate Receptors in Social Behavior in Rodents.International journal of molecular sciences · 2019Review
- Sex-associated differences in excitability within the bed nucleus of the stria terminalis are reflective of cell-type.Neurobiology of stress · 2019Article
- Functions of medial hypothalamic and mesolimbic dopamine circuitries in aggression.Current opinion in behavioral sciences · 2018Article
- Age and sex differences in oxytocin and vasopressin V1a receptor binding densities in the rat brain: focus on the social decision-making network.Brain structure & function · 2017Article
- Involvement of the oxytocin system in the bed nucleus of the stria terminalis in the sex-specific regulation of social recognition.Psychoneuroendocrinology · 2016Article
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Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metabotropic glutamate receptor subtype 7 (mGluR7) is a member of group III mGluRs, which localize to the presynaptic active zones of the mammalian central nervous system. Although histological, genetic, and electrophysiological studies ensure the importance of mGluR7, its roles in behavior and physiology remain largely unknown. Using a resident-intruder paradigm, we found a severe reduction in intermale aggressive behavior in mGluR7 knockout (KO) mice. We also found alterations in other social behaviors in male mGluR7 KO mice, including sexual behavior toward male intruders. Because olfaction is critical for rodent social behavior, including aggression, we performed an olfaction test, finding that mGluR7 KO mice failed to show interest in the smell of male urine. To clarify the olfactory deficit, we then exposed mice to urine and analyzed c-Fos-immunoreactivity, discovering a remarkable reduction in neural activity in the bed nucleus of the stria terminalis (BNST) of mGluR7 KO mice. Finally, intra-BNST administration of the mGluR7-selective antagonist 6-(4-methoxyphenyl)-5-methyl-3-pyridin-4-ylisoxazolo[4,5-c]pyridin-4(5H)-one (MMPIP) also reproduced the phenotype of mGluR7 KO mice, including reduced aggression and altered social interaction. Thus mGluR7 may work as an 'enhancer of neural activity' in the BNST and is important for intermale aggression. Our findings demonstrate that mGluR7 is essential for social behavior and innate behavior. Our study on mGluR7 in the BNST will shed light on future therapies for emotional disorders in humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.