ArticlePhysiological reports2015
Cerebrovascular regulation in men and women: stimulus-specific role of cyclooxygenase.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Nitric oxide synthase inhibition in healthy adults reduces regional and total cerebral macrovascular blood flow and microvascular perfusion.The Journal of physiology · 2021Trial
- Carbon dioxide-mediated vasomotion of extra-cranial cerebral arteries in humans: a role for prostaglandins?The Journal of physiology · 2016Trial
- Sex comparison of cerebrovascular reactivity to COJournal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Article
- Systolic versus diastolic differences in cerebrovascular reactivity to hypercapnic and hypocapnic challenges.European journal of applied physiology · 2025Article
- Sex differences in gray matter, white matter, and regional brain perfusion in young, healthy adults.American journal of physiology. Heart and circulatory physiology · 2024Article
- Hemoglobin and cerebral hypoxic vasodilation in humans: Evidence for nitric oxide-dependent andJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023Article
- Reduced basal macrovascular and microvascular cerebral blood flow in young adults with metabolic syndrome: potential mechanisms.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- The relationships between age, sex, and cerebrovascular reactivity to hypercapnia using traditional and kinetic-based analyses in healthy adults.American journal of physiology. Heart and circulatory physiology · 2022Article
- Menstrual phase influences cerebrovascular responsiveness in females but may not affect sex differences.Frontiers in physiology · 2022Article
- Cerebrovascular responses to graded exercise in young healthy males and females.Physiological reports · 2020Article
- Sex differences in the structure and function of rat middle cerebral arteries.American journal of physiology. Heart and circulatory physiology · 2020Article
- Comparable blood velocity changes in middle and posterior cerebral arteries during and following acute high-intensity exercise in young fit women.Physiological reports · 2020Article
- Differential contribution of cyclooxygenase to basal cerebral blood flow and hypoxic cerebral vasodilation.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Cerebrovascular reactivity and cerebral autoregulation are improved in the supine posture compared to upright in healthy men and women.PloS one · 2020Article
- Swimming-related effects on cerebrovascular and cognitive function.Physiological reports · 2019Article
- Severe Hypoxia Does Not Offset the Benefits of Exercise on Cognitive Function in Sedentary Young Women.International journal of environmental research and public health · 2019Article
- Age-Related Reductions in Cerebrovascular Reactivity Using 4D Flow MRI.Frontiers in aging neuroscience · 2019Article
- Chemoreflex function and brain blood flow during upright posture in men and women.Physiological reports · 2018Article
- Cerebrovascular Hemodynamics in Women.Seminars in neurology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Greater cerebral artery vasodilation mediated by cyclooxygenase (COX) in female animals is unexplored in humans. We hypothesized that young, healthy women would exhibit greater basal cerebral blood flow (CBF) and greater vasodilation during hypoxia or hypercapnia compared to men, mediated by a larger contribution of COX. We measured middle cerebral artery velocity (MCAv, transcranial Doppler ultrasound) in 42 adults (24 women, 18 men; 24 ± 1 years) during two visits, in a double-blind, placebo-controlled design (COX inhibition, 100 mg oral indomethacin, Indo). Women were studied early in the follicular phase of the menstrual cycle (days 1-5). Two levels of isocapnic hypoxia (SPO2 = 90% and 80%) were induced for 5-min each. Separately, hypercapnia was induced by increasing end-tidal carbon dioxide (PETCO 2) 10 mmHg above baseline. A positive change in MCAv (ΔMCAv) reflected vasodilation. Basal MCAv was greater in women compared to men (P < 0.01) across all conditions. Indo decreased baseline MCAv (P < 0.01) similarly between sexes. Hypoxia increased MCAv (P < 0.01), but ΔMCAv was not different between sexes. Indo did not alter hypoxic vasodilation in either sex. Hypercapnia increased MCAv (P < 0.01), but ΔMCAv was not different between sexes. Indo elicited a large decrease in hypercapnic vasodilation (P < 0.01) that was similar between sexes. During the early follicular phase, women exhibit greater basal CBF than men, but similar vasodilatory responses to hypoxia and hypercapnia. Moreover, COX is not obligatory for hypoxic vasodilation, but plays a vital and similar role in the regulation of basal CBF (~30%) and hypercapnic response (~55%) between sexes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.