Evidence map›Paper›PMID 26149207›Full record

ArticleEnvironmental health perspectives2016

Near-Roadway Air Pollution and Coronary Heart Disease: Burden of Disease and Potential Impact of a Greenhouse Gas Reduction Strategy in Southern California.

Rakesh Ghosh, Frederick Lurmann, Laura Perez, Bryan Penfold, Sylvia Brandt, John Wilson, Meredith Milet, Nino Künzli, Rob McConnell

Abstract read
In one paragraph

Article in Environmental health perspectives, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Residential proximity to major roads and fecundability in a preconception cohort.Environmental epidemiology (Philadelphia, Pa.) · 2020
    Article
  9. Article
  10. Conditions Leading to Elevated PMInternational journal of environmental research and public health · 2019
    Article
  11. Article
  12. Article
  13. Finely Resolved On-Road PMRisk analysis : an official publication of the Society for Risk Analysis · 2017
    Article
  14. Article
  15. Article
  16. Traffic-related air pollution is associated with cardio-metabolic biomarkers in general residents.International archives of occupational and environmental health · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rakesh GhoshDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
Frederick Lurmann
Laura Perez
Bryan Penfold
Sylvia Brandt
John Wilson
Meredith Milet
Nino Künzli
Rob McConnell

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
Urban Air Pollution and Children's Respiratory HealthP01ES011627 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GILLILAND, FRANK D. · 2002 to 2011
$30.2M
Southern California Children's Environmental Health Center (SC-CEHC)P01ES022845 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HRICKO, ANDREA M · 2013 to 2018
$4.0M
Childhood Asthma, Susceptibility and Biological Activity of Ambient ParticlesR01ES016535 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCCONNELL, ROB S · 2008 to 2011
$2.0M
NIEHS NIH HHS P01 ES011627NIEHS NIH HHS P01 ES022845NIEHS NIH HHS P30 ES007048NIEHS NIH HHS R01 ES016535
6 · The paper itself

Abstract

backgroundSeveral studies have estimated the burden of coronary heart disease (CHD) mortality from ambient regional particulate matter ≤ 2.5 μm (PM2.5). The burden of near-roadway air pollution (NRAP) generally has not been examined, despite evidence of a causal link with CHD.

objectiveWe investigated the CHD burden from NRAP and compared it with the PM2.5 burden in the California South Coast Air Basin for 2008 and under a compact urban growth greenhouse gas reduction scenario for 2035.

methodsWe estimated the population attributable fraction and number of CHD events attributable to residential traffic density, proximity to a major road, elemental carbon (EC), and PM2.5 compared with the expected disease burden if the population were exposed to background levels of air pollution.

resultsIn 2008, an estimated 1,300 CHD deaths (6.8% of the total) were attributable to traffic density, 430 deaths (2.4%) to residential proximity to a major road, and 690 (3.7%) to EC. There were 1,900 deaths (10.4%) attributable to PM2.5. Although reduced exposures in 2035 should result in smaller fractions of CHD attributable to traffic density, EC, and PM2.5, the numbers of estimated deaths attributable to each of these exposures are anticipated to increase to 2,500, 900, and 2,900, respectively, due to population aging. A similar pattern of increasing NRAP-attributable CHD hospitalizations was estimated to occur between 2008 and 2035.

conclusionThese results suggest that a large burden of preventable CHD mortality is attributable to NRAP and is likely to increase even with decreasing exposure by 2035 due to vulnerability of an aging population. Greenhouse gas reduction strategies developed to mitigate climate change offer unexploited opportunities for air pollution health co-benefits.

Indexed as

Environmental ExposureAdolescentAdultAgedAged, 80 and overAir PollutantsCaliforniaChildChild, PreschoolCoronary Artery DiseaseEnvironmental MonitoringHumansInfantInfant, NewbornMiddle AgedParticulate MatterAir PollutantsParticulate MatterVehicle Emissions

Identifiers

PMID26149207
PMCPMC4749075

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.