Evidence map›Paper›PMID 26149120›Full record

ArticleMedical science monitor : international medical journal of experimental and clinical research2015

Vitamin D Deficiency in Uygurs and Kazaks Is Associated with Polymorphisms in CYP2R1 and DHCR7/NADSYN1 Genes.

Xinjuan Xu, Jiangfeng Mao, Mingchen Zhang, Haiming Liu, Haixia Li, Hong Lei, Lu Han, Min Gao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medical science monitor : international medical journal of experimental and clinical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 4 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 4 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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  6. CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
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  18. Is Nasal Polyposis Related to Levels of Serum Vitamin D and Vitamin D Receptor Gene Expression?Medical science monitor : international medical journal of experimental and clinical research · 2016
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Xinjuan XuDepartment of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Jiangfeng MaoDepartment of Endocrinology, Peking Union Medical College Hospital, Key Laboratory of Endocrinology, Ministry of Health, Beijing, China (mainland).
Mingchen ZhangDepartment of Endocrinology, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Haiming LiuDepartment of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Haixia LiDepartment of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Hong LeiDepartment of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
Lu HanDepartment of Cardiology, Xinjiang Armed Police Hospital, Urumqi, Xinjiang, China (mainland).
Min GaoDepartment of Hypertension, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China (mainland).
First Affiliated Hospital of Xinjiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOur study is aimed to 1) clarify the vitamin D status in Uygur and Kazak ethnic populations and 2) elucidate the relationship between 14 SNPs (in 5 vitamin D-related genes) and vitamin D deficiency in these 2 ethnic populations. MATERIAL AND

methodsA multistage-cluster sampling survey was carried out for residents with Uygur or Kazak ethnicity in Xinjiang, China. Anthropometric measurements were taken and the concentrations of 25OHD were measured. Fourteen common variants in VDR, GC, CYP2R1, CYP27B1, and DHCR7/NADSYN1 were genotyped by using multiple SNaPshot assay. Logistic regression analysis was performed to identify the possible risk factors for vitamin D deficiency, after adjusting for several environmental and biological factors. The pattern of SNP associations was distinct between Uygurs and Kazaks.

resultsAnthropometric measurements and the concentrations of 25OHD were obtained from 1873 participants (945 Uygur ethnic and 928 Kazak ethnic). The genotypes of 14 SNPs were measured for 300 Uygurs and 300 Kazaks. The median 25OHD concentration was as low as 10.4 ng/ml in Uygurs and 16.2 ng/ml in Kazaks. In Uygurs, the prevalence of vitamin D deficiency, in-sufficiency, and sufficiency was 91.2%, 5.8%, and 3.0%, respectively. CYP2R1-rs10766197 was significantly associated with the presence of vitamin D deficiency in the Uygur ethnic population (P=0.019, OR=6.533, 95%C.I.: 361-31.357), while DHCR7/NADSYN1-rs12785878 was significantly associated with the presence of vitamin D deficiency in the Kazak ethnic population (P=0.011, OR=2.442, 95%C.I.: 1.224-4.873). Of 10 SNPs in VDR and GC genes, none was associated with vitamin D status in these 2 ethnic populations.

conclusionsVitamin D insufficiency is highly prevalent in Uygurs and Kazaks living in Xinjiang, China. Polymorphisms in CYP2R1-rs10766197 and DHCR7/NADSYN1-rs12785878 are associated with vitamin D deficiency in Uygur and Kazak ethnic populations.

Indexed as

Polymorphism, Single NucleotideAdultCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorChinaCholestanetriol 26-MonooxygenaseCytochrome P450 Family 2EthnicityFemaleHumansMaleMiddle AgedOxidoreductases Acting on CH-CH Group DonorsVitamin D Deficiency7-dehydrocholesterol reductaseCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCholestanetriol 26-MonooxygenaseCYP2R1 protein, humanCytochrome P450 Family 2NADSYN1 protein, humanOxidoreductases Acting on CH-CH Group Donors

Identifiers

PMID26149120
PMCPMC4501656
OpenAlexW2209743715

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.