Evidence map›Paper›PMID 26149026›Full record

ReviewJournal of thrombosis and haemostasis : JTH2015

Fibrinogen, red blood cells, and factor XIII in venous thrombosis.

B L Walton, J R Byrnes, A S Wolberg

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of thrombosis and haemostasis : JTH, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 82 citations in OpenAlex.

  1. Review
  2. Red blood cell-derived transglutaminase 2 influences thrombus formation.Research and practice in thrombosis and haemostasis · 2026
    Article
  3. Beyond Direct Fibrinolysis: Novel Approaches to Thrombolysis.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Universal new blood cell elution method with extensive phenotyping.Transfusion medicine (Oxford, England) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Fibrinolysis: an illustrated review.Research and practice in thrombosis and haemostasis · 2023
    Review
  16. Fibrinogen and Factor XIII in Venous Thrombosis and Thrombus Stability.Arteriosclerosis, thrombosis, and vascular biology · 2022
    Review
  17. Predicting value of fibrinogen in identifying cerebrovascular ischemic events in patients with dizziness/vertigo.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  18. Article
  19. Thrombus Structural Composition in Cardiovascular Disease.Arteriosclerosis, thrombosis, and vascular biology · 2021
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

B L WaltonDepartment of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
J R ByrnesDepartment of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
A S WolbergDepartment of Pathology and Laboratory Medicine and McAllister Heart Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · US

Funding

Determinants of Thrombus Structure and StabilityR56HL094740 · NHLBI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI WOLBERG, ALISA S. · 2014 to 2014
$378k
NHLBI NIH HHS R56 HL094740
6 · The paper itself

Abstract

Cardiovascular disease is the leading cause of death and disability worldwide. Among cardiovascular causes of death, venous thrombosis (VT) is ranked third most common in the world. Venous thrombi have high red blood cell and fibrin content; however, the pathophysiologic mechanisms that contribute to venous thrombus composition and stability are still poorly understood. This article reviews biological, biochemical, and biophysical contributions of fibrinogen, factor XIII, and red blood cells to VT, and new evidence suggesting interactions between these components mediate venous thrombus composition and size.

Indexed as

Blood CoagulationAnimalsErythrocytesFactor XIIIFibrinFibrinogenHumansProtein ConformationSignal TransductionStructure-Activity RelationshipVenous ThrombosisFactor XIIIFibrinFibrinogenclot retractionfactor XIIIfibrinogenplateletred blood cellvenous thrombosis

Identifiers

PMID26149026
PMCPMC5975093
OpenAlexW1579485518

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.