Evidence map›Paper›PMID 26148809›Full record

ReviewSurgery today2016

Pancreatic regeneration: basic research and gene regulation.

Kenji Okita, Toru Mizuguchi, Ota Shigenori, Masayuki Ishii, Toshihiko Nishidate, Tomomi Ueki, Makoto Meguro, Yasutoshi Kimura, Naoki Tanimizu, Norihisa Ichinohe and 6 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Surgery today, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Current topics in glycemic control by wearable artificial pancreas or bedside artificial pancreas with closed-loop system.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 1 country.

Kenji OkitaDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Toru MizuguchiDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan. tmizu@sapmed.ac.jp.
Ota ShigenoriDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Masayuki IshiiDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Toshihiko NishidateDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Tomomi UekiDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Makoto MeguroDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Yasutoshi KimuraDepartment of Surgery, Surgical Oncology, Sapporo Medical University, Sapporo, Hokkaido, 060-8543, Japan.
Naoki TanimizuDepartment of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
Norihisa IchinoheDepartment of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
Toshihiko TorigoeDepartment of Pathology I, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
Takashi KojimaDepartment of Cell Science, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
Toshihiro MitakaDepartment of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
Noriyuki SatoDepartment of Pathology I, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
Norimasa SawadaDepartment of Surgical Pathology II, Sapporo Medical University, Sapporo, Hokkaido, 060-8556, Japan.
Koichi HirataDepartment of Surgery, JR Sapporo Hospital, N-3, E-1, Chuo-Ku, Sapporo, Hokkaido, 060-0033, Japan.
Sapporo Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic regeneration (PR) is an interesting phenomenon that could provide clues as to how the control of diabetes mellitus might be achieved. Due to the different regenerative abilities of the pancreas and liver, the molecular mechanism responsible for PR is largely unknown. In this review, we describe five representative murine models of PR and thirteen humoral mitogens that stimulate β-cell proliferation. We also describe pancreatic ontogenesis, including the molecular transcriptional differences between α-cells and β-cells. Furthermore, we review 14 murine models which carry defects in genes related to key transcription factors for pancreatic ontogenesis to gain further insight into pancreatic development.

Indexed as

AnimalsCell ProliferationEpidermal Growth FactorGastrinsGene Expression Regulation, DevelopmentalGlucagon-Secreting CellsHumansIncretinsInsulin-Secreting CellsIntercellular Signaling Peptides and ProteinsMiceMice, KnockoutModels, AnimalPancreasRegenerationTranscription FactorsEpidermal Growth FactorGastrinsIncretinsIntercellular Signaling Peptides and ProteinsTranscription FactorsGene regulationPancreatic regenerationTranscriptional factors

Identifiers

PMID26148809
OpenAlexW777122542

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.