ArticleEnvironmental health : a global access science source2015
Perfluoroalkyl acids and time to pregnancy revisited: An update from the Danish National Birth Cohort.
Article in Environmental health : a global access science source, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Environmental Exposure to Per- and Polyfluorylalkyl Substances (PFASs) and Reproductive Outcomes in the General Population: A Systematic Review of Epidemiological Studies.International journal of environmental research and public health · 2024Pooled it
- Persistent organic pollutants and couple fecundability: a systematic review.Human reproduction update · 2021Pooled it
- Developmental exposure to perfluorooctane sulfonate(PFOS) impairs the endometrial receptivity.Scientific reports · 2025Article
- Perfluoroalkyl Acids in Follicular Fluid and Embryo Quality during IVF: A Prospective IVF Cohort in China.Environmental health perspectives · 2023Article
- Article
- Review
- Effect of Perfluorooctanesulfonic acid (PFOS) on immune cell development and function in mice.Immunology letters · 2021Article
- Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research.Environmental toxicology and chemistry · 2021Review
- Maternal Plasma Perfluoroalkyl Substances and Miscarriage: A Nested Case-Control Study in the Danish National Birth Cohort.Environmental health perspectives · 2020Article
- Perfluoroalkyl Substances and Maternal Thyroid Hormones in Early Pregnancy; Findings in the Danish National Birth Cohort.Environmental health perspectives · 2019Article
- Water and soil pollution as determinant of water and food quality/contamination and its impact on female fertility.Reproductive biology and endocrinology : RB&E · 2019Review
- Conditioning on Parity in Studies of Perfluoroalkyl Acids and Time to Pregnancy: An Example from the Danish National Birth Cohort.Environmental health perspectives · 2018Article
- Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort.International journal of environmental research and public health · 2018Article
- Organophosphate and Pyrethroid Pesticide Exposures Measured before Conception and Associations with Time to Pregnancy in Chinese Couples Enrolled in the Shanghai Birth Cohort.Environmental health perspectives · 2018Article
- Perfluoroalkyl substances and metabolic outcomes in pregnancy.Journal of public health and emergency · 2018Article
- Effects of Sample Handling and Analytical Procedures on Thyroid Hormone Concentrations in Pregnant Women's Plasma.Epidemiology (Cambridge, Mass.) · 2017Article
- Preconception perfluoroalkyl and polyfluoroalkyl substances and incident pregnancy loss, LIFE Study.Reproductive toxicology (Elmsford, N.Y.) · 2016Article
- Perfluoroalkyl Acid Concentrations in Blood Samples Subjected to Transportation and Processing Delay.PloS one · 2015Article
- Per- and Polyfluoroalkyl Substances: A National Priority for Safe Drinking Water.Public health reports (Washington, D.C. : 1974)Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe previously demonstrated an association between plasma perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and longer time to pregnancy (TTP) in a sample from the Danish National Birth Cohort (DNBC, 1996-2002). In this study we investigated this association in a new sample from the same cohort.
methodsSample 1 consisted of 440 women, and Sample 2 consisted of 1161 women from whom we previously published the associations between PFOS or PFOA and TTP. We performed sample-specific and pooled analyses using discrete-time survival analyses to estimate fecundability ratios according to PFOS and PFOA quartiles, adjusted for potential confounders chosen guided by a directed acyclic graph. We also estimated odds ratios for infertility (TTP > 12 months or infertility treatment) according to PFOS and PFOA by multivariable logistic regression.
resultsIn Sample 1 PFOS was not associated with lower fecundability ratios or infertility, and there was a tendency towards longer TTP with increasing PFOA only in parous women. In Sample 2 previously reported associations were again seen. In the pooled analyses including both parous and nulliparous women fecundability ratios were 13-22 % lower for the three higher quartiles of PFOS or PFOA compared to the reference quartile.
conclusionsThe pooled analyses were driven by the larger old sample, but we did not corroborate our previous finding of an association between high PFOS and longer TTP in the new sample. The tendency towards an association for PFOA and TTP in parous women may be due to reverse causation. Results from the new sample are more in line with the recent literature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.