Trial reportWorld journal of surgery2016
Diagnosis and Management of Bile Leaks After Hepatectomy: Results of a Prospective Analysis of 475 Hepatectomies.
Trial report in World journal of surgery, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02056028 (Validation of Our Policy of Long-term Drains Maintenance After Hepatic Resection), which is not on this map. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Validation of Our Policy of Long-term Drains Maintenance After Hepatic Resection: Results of a Prospective Cohort Analysis
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Risk factors of postoperative bile leakage after liver resection: A systematic review and meta-analysis.Cancer medicine · 2023Pooled it
- Meta-Analysis of Risk Factors for Bile Leakage After Hepatectomy Without Biliary Reconstruction.Frontiers in surgery · 2021Pooled it
- Pharmacological Modulation of Ischemic-Reperfusion Injury during Pringle Maneuver in Hepatic Surgery. A Prospective Randomized Pilot Study.World journal of surgery · 2016Trial
- Endoscopic management of biliary leaks: Where are we now?World journal of gastrointestinal endoscopy · 2025Review
- Long-Term Outcomes According to Surgical Margin in Mass-Forming Cholangiocarcinoma: The Role of R1vasc.Annals of surgical oncology · 2025Article
- Post-chemotherapy liver atrophy does not impact the outcome after hepatectomy performed under a parenchymal-sparing approach.Hepatobiliary surgery and nutrition · 2025Article
- Endoscopic or combined management of post-surgical biliary leaks: a two-center recent experience.Surgical endoscopy · 2024Article
- Impact of bile leak on the prognosis of patients with hepatocellular carcinoma who have undergone liver resection.Langenbeck's archives of surgery · 2024Article
- Anatomical liver resection using the ultrasound-guided compression technique in minimal access surgery.Surgical endoscopy · 2024Article
- A virtual biopsy of liver parenchyma to predict the outcome of liver resection.Updates in surgery · 2023Article
- Post-hepatectomy biliary leaks: analysis of risk factors and development of a simplified predictive scoring system.Langenbeck's archives of surgery · 2023Article
- Liver drains after surgery: what is the real practice? An international snapshot from the Li.DR.A.S. survey.Updates in surgery · 2022Article
- Stent-free duct-to-duct biliary reconstruction after hepatectomy for liver tumors involving biliary confluence at the hepatic hilum: a monocentric experience.Updates in surgery · 2021Article
- Robotic hepatic parenchymal transection: a two-surgeon technique using ultrasonic dissection and irrigated bipolar coagulation.Journal of robotic surgery · 2021Article
- Review
- Total upper transversal hepatectomy with outflow reconstruction for advanced mass-forming cholangiocarcinoma.Updates in surgery · 2021Article
- Hospital variation in use of prophylactic drains following hepatectomy.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2020Article
- Bile Leak Reduction with Laparoscopic Versus Open Liver Resection: A Multi-institutional Propensity Score-Adjusted Multivariable Regression Analysis.World journal of surgery · 2020Article
- Post-hepatectomy biliary fistula: from risk factors to the role of drain placement and management-still a lot to be answered.Hepatobiliary surgery and nutrition · 2019Article
- Dissecting the multinodular hepatocellular carcinoma subset: is there a survival benefit after hepatectomy?Updates in surgery · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis and management of bile leaks after hepatectomy are heterogeneous because there is no agreement on the definition of post-hepatectomy biliary fistula. The aim of this study was to validate our definition and management of biliary fistulas after hepatic resection and to compare our results with those proposed by other authors.
methodsA prospective series of patients who underwent hepatic resection from 2004 to 2012 were established. Drains were maintained for 7 days, and bilirubin was measured on postoperative days (PODs) 3, 5, and 7. Drains were removed if the bilirubin on POD 7 was less than that on POD 5 and less than 171 µmol/l (10 mg/dl). A statistical analysis of prognostic factors for biliary fistula was performed.
resultsAmong 475 consecutive patients, 39 (8%) had biliary fistulas. Only 8 (1.7%) patients required postoperative interventions. In comparison with other studies, we observed a higher rate of bile leaks, but at the same time, we observed a lower rate of interventional procedures. The area under the receiver operating characteristic curve on POD 7 had the highest predictive value (0.81; P < 0.001). Pringle maneuvers lasting ≥90 min (OR = 3.4; P < 0.001), extended resections (OR = 6.4; P = 0.007), blood transfusions (OR = 2.4; P = 0.035), and resections including segment I (OR = 1.9; P = 0.033) or segment V (OR = 1.8; P = 0.024) were independently associated with an increased risk of bile leak.
conclusionsThe proposed definition of biliary fistula provides effective recognition of those that are clinically relevant with a reduction of the risk of unrecognized collections and minimal postoperative morbidity. REGISTRATION NUMBER: NCT02056028 ( http://www.clinicaltrials.gov ).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.