Evidence map›Paper›PMID 26148506›Full record

ArticleCritical care (London, England)2015

Quantifying the healthcare costs of treating severely bleeding major trauma patients: a national study for England.

Helen E Campbell, Elizabeth A Stokes, Danielle N Bargo, Nicola Curry, Fiona E Lecky, Antoinette Edwards, Maralyn Woodford, Frances Seeney, Simon Eaglestone, Karim Brohi and 2 more

Abstract read
In one paragraph

Article in Critical care (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  5. Characteristics and outcomes of geriatric injuries presenting to an urban emergency department in Ghana.African journal of emergency medicine : Revue africaine de la medecine d'urgence · 2025
    Article
  6. Utility of point of care viscoelastic haemostatic assays for trauma patients in the emergency department.Scandinavian journal of trauma, resuscitation and emergency medicine · 2025
    Observational
  7. Article
  8. Article
  9. Article
  10. Article
  11. Multiple Trauma and Emergency Room Management.Deutsches Arzteblatt international · 2017
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Helen E CampbellHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Headington, Oxford, OX3 7LF, UK. helen.campbell@dph.ox.ac.uk.
Elizabeth A StokesHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Headington, Oxford, OX3 7LF, UK. elizabeth.stokes@dph.ox.ac.uk.
Danielle N BargoEli Lilly and Company Limited, Lilly House, Priestley Road, Basingstoke, Hampshire, RG24 9NL, UK. bargo_danielle_nicole@lilly.com.
Nicola CurryOxford Haemophilia and Thrombosis Centre, Oxford University Hospitals NHS Trust, Churchill Hospital, Oxford, OX3 7LE, UK. Nicola.Curry@ouh.nhs.uk.
Fiona E LeckyTrauma Audit and Research Network, 3rd Floor Mayo Building, Salford Royal NHS Foundation Trust, Salford, M6 8HD, UK. fiona.lecky@manchester.ac.uk.
Antoinette EdwardsTrauma Audit and Research Network, 3rd Floor Mayo Building, Salford Royal NHS Foundation Trust, Salford, M6 8HD, UK. Antoinette.Edwards@manchester.ac.uk.
Maralyn WoodfordTrauma Audit and Research Network, 3rd Floor Mayo Building, Salford Royal NHS Foundation Trust, Salford, M6 8HD, UK. Maralyn.Woodford@manchester.ac.uk.
Frances SeeneyNHS Blood and Transplant Clinical Trials Unit, Fox Den Road, Stoke Gifford, Bristol, BS34 8RR, UK. Frances.Seeney@nhsbt.nhs.uk.
Simon EaglestoneBlizard Institute, Barts and The London School of Medicine and Dentistry, The Blizard Building, 4 Newark Street, London, E1 2AT, UK. s.eaglestone@qmul.ac.uk.
Karim BrohiBlizard Institute, Barts and The London School of Medicine and Dentistry, The Blizard Building, 4 Newark Street, London, E1 2AT, UK. k.brohi@qmul.ac.uk.
Alastair M GrayHealth Economics Research Centre, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Headington, Oxford, OX3 7LF, UK. alastair.gray@dph.ox.ac.uk.
Simon J StanworthNHS Blood and Transplant and Oxford University Hospitals NHS Trust, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9BQ, UK. simon.stanworth@nhsbt.nhs.uk.

Funding

Department of Health RP-PG-0407-10036
6 · The paper itself

Abstract

introductionSeverely bleeding trauma patients are a small proportion of the major trauma population but account for 40% of all trauma deaths. Healthcare resource use and costs are likely to be substantial but have not been fully quantified. Knowledge of costs is essential for developing targeted cost reduction strategies, informing health policy, and ensuring the cost-effectiveness of interventions.

methodsIn collaboration with the Trauma Audit Research Network (TARN) detailed patient-level data on in-hospital resource use, extended care at hospital discharge, and readmissions up to 12 months post-injury were collected on 441 consecutive adult major trauma patients with severe bleeding presenting at 22 hospitals (21 in England and one in Wales). Resource use data were costed using national unit costs and mean costs estimated for the cohort and for clinically relevant subgroups. Using nationally available data on trauma presentations in England, patient-level cost estimates were up-scaled to a national level.

resultsThe mean (95% confidence interval) total cost of initial hospital inpatient care was £19,770 (£18,177 to £21,364) per patient, of which 62% was attributable to ventilation, intensive care, and ward stays, 16% to surgery, and 12% to blood component transfusion. Nursing home and rehabilitation unit care and re-admissions to hospital increased the cost to £20,591 (£18,924 to £22,257). Costs were significantly higher for more severely injured trauma patients (Injury Severity Score ≥15) and those with blunt injuries. Cost estimates for England were £148,300,000, with over a third of this cost attributable to patients aged 65 years and over.

conclusionsSeverely bleeding major trauma patients are a high cost subgroup of all major trauma patients, and the cost burden is projected to rise further as a consequence of an aging population and as evidence continues to emerge on the benefits of early and simultaneous administration of blood products in pre-specified ratios. The findings from this study provide a previously unreported baseline from which the potential impact of changes to service provision and/or treatment practice can begin to be evaluated. Further studies are still required to determine the full costs of post-discharge care requirements, which are also likely to be substantial.

Indexed as

Hospital CostsAdultAgedBlood Component TransfusionCritical CareEmergency Medical ServicesEmergency Service, HospitalEnglandFemaleHemorrhageHospitalizationHumansInjury Severity ScoreMaleMedical AuditMiddle Aged

Identifiers

PMID26148506
PMCPMC4517367

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.