Evidence map›Paper›PMID 26148135›Full record

ArticleMovement disorders : official journal of the Movement Disorder Society2015

Distinct patterns of brain activity in progressive supranuclear palsy and Parkinson's disease.

Roxana G Burciu, Edward Ofori, Priyank Shukla, Peggy J Planetta, Amy F Snyder, Hong Li, Chris J Hass, Michael S Okun, Nikolaus R McFarland, David E Vaillancourt

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 4 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.

  1. Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling.Movement disorders : official journal of the Movement Disorder Society · 2021
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Behavioral Classification of Sequential Neural Activity Using Time Varying Recurrent Neural Networks.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Dysfunction of motor cortices in Parkinson's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024
    Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Roxana G BurciuDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Edward OforiDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Priyank ShuklaDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Peggy J PlanettaDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Amy F SnyderDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Hong LiDepartment of Preventive Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Chris J HassDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
Michael S OkunCenter for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, USA.
Nikolaus R McFarlandCenter for Movement Disorders and Neurorestoration, University of Florida, Gainesville, Florida, USA.
David E VaillancourtDepartment of Applied Physiology and Kinesiology, University of Florida, Gainesville, Florida, USA.
University of Florida · USRush University Medical Center · US

Funding

Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2M
UF Clinical and Translational Science AwardUL1TR000064 · NCATS · UNIVERSITY OF FLORIDA · PI NELSON, DAVID R · 2012 to 2014
$12.2M
Scaling and Sequencing Motor Output in Humans: fMRI StudyR01NS052318 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VAILLANCOURT, DAVID E · 2005 to 2020
$6.0M
Non-Invasive Markers of Neurodegeneration in Movement DisordersR01NS075012 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING, VAILLANCOURT, DAVID E · 2012 to 2022
$4.1M
Interdisciplinary Training in Movement Disorders and NeurorestorationT32NS082168 · NINDS · UNIVERSITY OF FLORIDA · PI Melissa Jo Armstrong, David E Vaillancourt · 2015 to 2026
$2.8M
NCATS NIH HHS UL1 TR000064NCATS NIH HHS UL1 TR001427NINDS NIH HHS R01 NS052318NINDS NIH HHS R01 NS075012NINDS NIH HHS T32 NS082168
6 · The paper itself

Abstract

The basal ganglia-thalamo-cortical and cerebello-thalamo-cortical circuits are important for motor control. Whether their functioning is affected in a similar or different way by progressive supranuclear palsy (PSP) and Parkinson's disease (PD) is not clear. A functional magnetic resonance imaging (fMRI) force production paradigm and voxel-based morphometry were used to assess differences in brain activity and macrostructural volumes between PSP, PD, and healthy age-matched controls. We found that PSP and PD share reduced functional activity of the basal ganglia and cortical motor areas, but this is more pronounced in PSP than in PD. In PSP the frontal regions are underactive, whereas the posterior parietal and occipital regions are overactive as compared with controls and PD. Furthermore, lobules I through IV, V, and VI of the cerebellum are hypoactive in PSP and PD, whereas Crus I and lobule IX are hyperactive in PSP only. Reductions in gray and white matter volume are specific to PSP. Finally, the functional status of the caudate as well as the volume of the superior frontal gyrus predict clinical gait and posture measures in PSP. PSP and PD share hypoactivity of the basal ganglia, motor cortex, and anterior cerebellum. These patients also display a unique pattern, such that anterior regions of the cortex are hypoactive and posterior regions of the cortex and cerebellum are hyperactive. Together, these findings suggest that specific structures within the basal ganglia, cortex, and cerebellum are affected differently in PSP relative to PD.

Indexed as

AgedAnalysis of VarianceBrainFemaleHand StrengthHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedOxygenParkinson DiseaseSeverity of Illness IndexSupranuclear Palsy, ProgressiveOxygenforcefunctional MRImotor circuitsParkinson's diseaseprogressive supranuclear palsy

Identifiers

PMID26148135
PMCPMC4578977
OpenAlexW1594054574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.