ArticlePloS one2015
Specialized Cortex Glial Cells Accumulate Lipid Droplets in Drosophila melanogaster.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 90 citations in OpenAlex.
- Sex-biased expression of enteroendocrine cell-derived hormones contributes to higher fat storage ineLife · 2026Article
- Neuro-glial lipid imbalance in a Drosophila model of amyotrophic lateral sclerosis 8.Acta neuropathologica communications · 2026Article
- Peroxisomal import is circadian in glia and regulates sleep and lipid metabolism.PLoS biology · 2026Article
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- Glia-derived noncanonical fatty acid binding protein modulates brain lipid storage and clearance.Science advances · 2025Article
- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- Health impacts of asphalt emissions: Examining neurological risks and the need for long-term exposure mitigation.Journal of hazardous materials · 2025Article
- HIV-TAT dysregulates microglial lipid metabolism through SREBP2/miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV.Brain, behavior, and immunity · 2025Article
- Diverting glial glycolytic flux towards neurons is a memory-relevant role of Drosophila CRH-like signalling.Nature communications · 2024Article
- A novelFly · 2024Article
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- scRNA-seq data from the larval Drosophila ventral cord provides a resource for studying motor systems function and development.Developmental cell · 2024Article
- Glial metabolism versatility regulates mushroom body-driven behavioral output inLearning & memory (Cold Spring Harbor, N.Y.) · 2024Review
- A neuron-glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis.Nature neuroscience · 2024Article
- Glycolysis-derived alanine from glia fuels neuronal mitochondria for memory in Drosophila.Nature metabolism · 2023Article
- Analysis of cnidarian Gcm suggests a neuronal origin of glial EAAT1 function.Scientific reports · 2023Article
- Bioorthogonal Stimulated Raman Scattering Imaging Uncovers Lipid Metabolic Dynamics inGEN biotechnology · 2023Article
- Ensheathing glia promote increased lifespan and healthy brain aging.Aging cell · 2023Article
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Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid droplets (LDs) are common organelles of the majority of eukaryotic cell types. Their biological significance has been extensively studied in mammalian liver cells and white adipose tissue. Although the central nervous system contains the highest relative amount and the largest number of different lipid species, neither the spatial nor the temporal distribution of LDs has been described. In this study, we used the brain of the fruitfly, Drosophila melanogaster, to investigate the neuroanatomy of LDs. We demonstrated that LDs are exclusively localised in glial cells but not in neurons in the larval nervous system. We showed that the brain's LD pool, rather than being constant, changes dynamically during development and reaches its highest value at the beginning of metamorphosis. LDs are particularly enriched in cortex glial cells located close to the brain surface. These specialized superficial cortex glial cells contain the highest amount of LDs among glial cell types and encapsulate neuroblasts and their daughter cells. Superficial cortex glial cells, combined with subperineurial glial cells, express the Drosophila fatty acid binding protein (Dfabp), as we have demonstrated through light- and electron microscopic immunocytochemistry. To the best of our best knowledge this is the first study that describes LD neuroanatomy in the Drosophila larval brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.