Evidence map›Paper›PMID 26148003›Full record

Trial reportMovement disorders : official journal of the Movement Disorder Society2015

Exercise improves cognition in Parkinson's disease: The PRET-PD randomized, clinical trial.

Fabian J David, Julie A Robichaud, Sue E Leurgans, Cynthia Poon, Wendy M Kohrt, Jennifer G Goldman, Cynthia L Comella, David E Vaillancourt, Daniel M Corcos

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Movement disorders : official journal of the Movement Disorder Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04012086 (Intensive Physical Therapy Mitigates Cognitive Decline in People With Parkinson's Disease), which is not on this map. Cited by 87 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed, 9 pooled it
14.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04012086 nacompletednot on this map

Intensive Physical Therapy Mitigates Cognitive Decline in People With Parkinson's Disease

TypeinterventionalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2015 to 2018Enrolled40ConditionsParkinson Disease, Cognitive ImpairmentArmsPhysical therapy
3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 9 syntheses or guidelines pooled it, 183 citations in OpenAlex.

  1. Pooled it
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  5. Guideline
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  9. Virtual reality for rehabilitation in Parkinson's disease.The Cochrane database of systematic reviews · 2016
    Pooled it
  10. Trial
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  16. Physical Activity and Exercise for People with Parkinson's Disease: The Past, Present, and Future.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  17. Article
  18. Review
  19. Review
  20. Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Fabian J DavidDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois, USA.
Julie A RobichaudDepartment of Physical Therapy, University of Illinois at Chicago, Chicago, Illinois, USA.
Sue E LeurgansDepartments of Neurological Sciences and Preventive Medicine, Rush University Medical Center, Chicago, Illinois, USA.
Cynthia PoonDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois, USA.
Wendy M KohrtDivision of Geriatric Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA.
Jennifer G GoldmanDepartment of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Rush University Medical Center, Chicago, Illinois, USA.
Cynthia L ComellaDepartment of Neurological Sciences, Section of Parkinson Disease and Movement Disorders, Rush University Medical Center, Chicago, Illinois, USA.
David E VaillancourtDepartments of Applied Physiology and Kinesiology, Biomedical Engineering, and Neurology, University of Florida, Gainesville, Florida, USA.
Daniel M CorcosDepartment of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois, USA.
Rush University Medical Center · USNorthwestern University · USUniversity of Colorado Denver · USUniversity of Florida · USUniversity of Illinois Chicago · US

Funding

Scaling and Sequencing Motor Output in Humans: fMRI StudyR01NS052318 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI VAILLANCOURT, DAVID E · 2005 to 2020
$6.0M
Non-Invasive Markers of Neurodegeneration in Movement DisordersR01NS075012 · NINDS · UNIVERSITY OF FLORIDA · PI LI, YUQING, VAILLANCOURT, DAVID E · 2012 to 2022
$4.1M
MOTOR DEFICITS--EXPERIMENTAL AND CLINICAL CORRELATESR01NS028127 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI CORCOS, DANIEL M. · 1993 to 2011
$4.0M
NINDS NIH HHS R01 NS028127NINDS NIH HHS R01 NS052318NINDS NIH HHS R01 NS075012NINDS NIH HHS R01-NS28127-12NINDS NIH HHS R01-NS28127-13NINDS NIH HHS R01-NS28127-14NINDS NIH HHS R01-NS28127-15NINDS NIH HHS R01-NS28127-16NINDS NIH HHS R01 NS52318NINDS NIH HHS R01 NS75012
6 · The paper itself

Abstract

backgroundThis article reports on the findings of the effect of two structured exercise interventions on secondary cognitive outcomes that were gathered as part of the Progressive Resistance Exercise Training in Parkinson's disease (PD) randomized, controlled trial.

methodsThis study was a prospective, parallel-group, single-center trial. Fifty-one nondemented patients with mild-to-moderate PD were randomly assigned either to modified Fitness Counts (mFC) or to Progressive Resistance Exercise Training (PRET) and were followed for 24 months. Cognitive outcomes were the Digit Span, Stroop, and Brief Test of Attention (BTA).

resultsEighteen patients in mFC and 20 patients in PRET completed the trial. At 12 and at 24 months, no differences between groups were observed. At 12 months, relative to baseline, mFC improved on the Digit Span (estimated change: 0.3; interquartile range: 0, 0.7; P = 0.04) and Stroop (0.3; 0, 0.6; P = 0.04), and PRET improved only on the Digit Span (0.7; 0.3, 1; P < 0.01). At 24 months, relative to baseline, mFC improved on the Digit Span (0.7; 0.3, 1.7; P < 0.01) and Stroop (0.3; 0.1, 0.5; P = 0.03), whereas PRET improved on the Digit Span (0.5; 0.2, 0.8; P < 0.01), Stroop (0.2; -0.1, 0.6; P = 0.048), and BTA (0.3; 0, 0.8; P = 0.048). No neurological or cognitive adverse events were observed.

conclusionsThis study provides class IV level of evidence that 24 months of PRET or mFC may improve attention and working memory in nondemented patients with mild-to-moderate Parkinson's disease.

Indexed as

AgedCognition DisordersExercise TherapyFemaleFollow-Up StudiesHumansMaleMental Status ScheduleMiddle AgedNeuropsychological TestsParkinson DiseaseSeverity of Illness IndexSingle-Blind MethodStatistics, NonparametricTime FactorsTreatment OutcomeattentionmemoryParkison's diseaseprogressive resistance exerciserandomized controlled trial

Identifiers

PMID26148003
PMCPMC4609235
OpenAlexW1546336211

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.