Evidence map›Paper›PMID 26147963›Full record

Trial reportPloS one2015

Incidence and Geographic Distribution of Extensively Drug-Resistant Tuberculosis in KwaZulu-Natal Province, South Africa.

Jennifer R Lim, Neel R Gandhi, Thuli Mthiyane, Koleka Mlisana, Julie Moodley, Prenika Jaglal, Neeshan Ramdin, James C M Brust, Nazir Ismail, Roxana Rustomjee and 1 more

Abstract readClinical TrialMulticenter Study
In one paragraph

Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Extensively drug-resistant tuberculosis 'hotspots' and sociodemographic associations in Durban, South Africa.The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease · 2019
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jennifer R LimAlbert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Neel R GandhiAlbert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America; Emory University Rollins School of Public Health, Atlanta, Georgia, United States of America.
Thuli MthiyaneUniversity of KwaZulu-Natal, Durban, South Africa.
Koleka MlisanaUniversity of KwaZulu-Natal, Durban, South Africa; National Health Laboratory Service, Durban, South Africa.
Julie MoodleyNational Health Laboratory Service, Durban, South Africa.
Prenika JaglalNational Health Laboratory Service, Durban, South Africa.
Neeshan RamdinCentre for Tuberculosis, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa.
James C M BrustAlbert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.
Nazir IsmailCentre for Tuberculosis, National Institute for Communicable Diseases, National Health Laboratory Service, Johannesburg, South Africa; Department of Medical Microbiology, University of Pretoria, Pretoria, South Africa.
Roxana RustomjeeMedical Research Council, Cape Town, South Africa.
N Sarita ShahAlbert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, United States of America.

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Immunology/Pathology CoreP30AI051519 · NIAID · YESHIVA UNIVERSITY · PI GOLDSTEIN, HARRIS · 2003 to 2013
$18.6M
Impact of HIV, Antiretroviral Therapy and TB Genotype on Survival in MDR TBR01AI087465 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2010 to 2014
$3.9M
Transmission of HIV-Associated XDR TB in Rural South AfricaR01AI089349 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2010 to 2014
$3.7M
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global HealthK24AI114444 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2014 to 2023
$1.8M
Integrated, Home-based Treatment for MDR TB and HIV in Rural South AfricaK23AI083088 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BRUST, JAMES C M · 2010 to 2014
$665k
NIAID NIH HHS K23 AI083088NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI051519NIAID NIH HHS R01 AI087465NIAID NIH HHS R01 AI089349PHS HHS NIAID K24 114444
6 · The paper itself

Abstract

South Africa is experiencing a widespread drug-resistant tuberculosis epidemic, although data are limited regarding the current situation. This study finds that the extensively drug-resistant tuberculosis (XDR-TB) incidence in KwaZulu-Natal increased to 3.5 cases/100,000 (776 cases) in 2011-2012. XDR-TB cases are widely distributed geographically, with the majority of districts experiencing a rise in incidence.

Indexed as

AdolescentAdultAgedChildChild, PreschoolExtensively Drug-Resistant TuberculosisFemaleHumansIncidenceMaleMiddle AgedSouth Africa

Identifiers

PMID26147963
PMCPMC4493033

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.