ArticlePloS one2015
Dose Optimization in TOF-PET/MR Compared to TOF-PET/CT.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Reduction of [EJNMMI physics · 2024Article
- BSREM for Brain Metastasis Detection with 18F-FDG-PET/CT in Lung Cancer Patients.Journal of digital imaging · 2022Article
- Medical Radiation Exposure Reduction in PET via Super-Resolution Deep Learning Model.Diagnostics (Basel, Switzerland) · 2022Article
- Reproducibility of Standardized Uptake Values Including Volume Metrics Between TOF-PET-MR and TOF-PET-CT.Frontiers in medicine · 2022Article
- An international expert opinion statement on the utility of PET/MR for imaging of skeletal metastases.European journal of nuclear medicine and molecular imaging · 2021Article
- Dose Reduction in Brain [Molecular imaging and biology · 2020Article
- Assessing time-of-flight signal-to-noise ratio gains within the myocardium and subsequent reductions in administered activity in cardiac PET studies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- [Molecular imaging and biology · 2018Article
- Impact of a Bayesian penalized likelihood reconstruction algorithm on image quality in novel digital PET/CT: clinical implications for the assessment of lung tumors.EJNMMI physics · 2018Article
- Advances in PET/MR instrumentation and image reconstruction.The British journal of radiology · 2018Review
- Advanced Functional Tumor Imaging and Precision Nuclear Medicine Enabled by Digital PET Technologies.Contrast media & molecular imaging · 2017Review
- Reaching 200-ps timing resolution in a time-of-flight and depth-of-interaction positron emission tomography detector using phosphor-coated crystals and high-density silicon photomultipliers.Journal of medical imaging (Bellingham, Wash.) · 2016Article
- Combined PET/MRI: from Status Quo to Status Go. Summary Report of the Fifth International Workshop on PET/MR Imaging; February 15-19, 2016; Tübingen, Germany.Molecular imaging and biology · 2016Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the possible activity reduction in FDG-imaging in a Time-of-Flight (TOF) PET/MR, based on cross-evaluation of patient-based NECR (noise equivalent count rate) measurements in PET/CT, cross referencing with phantom-based NECR curves as well as initial evaluation of TOF-PET/MR with reduced activity. MATERIALS AND
methodsA total of 75 consecutive patients were evaluated in this study. PET/CT imaging was performed on a PET/CT (time-of-flight (TOF) Discovery D 690 PET/CT). Initial PET/MR imaging was performed on a newly available simultaneous TOF-PET/MR (Signa PET/MR). An optimal NECR for diagnostic purposes was defined in clinical patients (NECRP) in PET/CT. Subsequent optimal activity concentration at the acquisition time ([A]0) and target NECR (NECRT) were obtained. These data were used to predict the theoretical FDG activity requirement of the new TOF-PET/MR system. Twenty-five initial patients were acquired with (retrospectively reconstructed) different imaging times equivalent for different activities on the simultaneous PET/MR for the evaluation of clinically realistic FDG-activities.
resultsThe obtained values for NECRP, [A]0 and NECRT were 114.6 (± 14.2) kcps (Kilocounts per second), 4.0 (± 0.7) kBq/mL and 45 kcps, respectively. Evaluating the NECRT together with the phantom curve of the TOF-PET/MR device, the theoretical optimal activity concentration was found to be approximately 1.3 kBq/mL, which represents 35% of the activity concentration required by the TOF-PET/CT. Initial evaluation on patients in the simultaneous TOF-PET/MR shows clinically realistic activities of 1.8 kBq/mL, which represent 44% of the required activity.
conclusionThe new TOF-PET/MR device requires significantly less activity to generate PET-images with good-to-excellent image quality, due to improvements in detector geometry and detector technologies. The theoretically achievable dose reduction accounts for up to 65% but cannot be fully translated into clinical routine based on the coils within the FOV and MR-sequences applied at the same time. The clinically realistic reduction in activity is slightly more than 50%. Further studies in a larger number of patients are needed to confirm our findings.
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