ArticleACS applied materials & interfaces2015
Poly(acrylic acid) Bridged Gadolinium Metal-Organic Framework-Gold Nanoparticle Composites as Contrast Agents for Computed Tomography and Magnetic Resonance Bimodal Imaging.
Article in ACS applied materials & interfaces, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 108 citations in OpenAlex.
- Enhanced separation of europium radionuclides from active solutions using a novel sorbent of gadolinium metal-organic framework.RSC advances · 2025Article
- One-pot hydrothermal synthesize and characterization of Au/Gd bimetallic nanostructure as potential contrast agents in CT and MR imaging.BioImpacts : BI · 2025Article
- Application of rare earth elements in dual-modality molecular probes.RSC advances · 2024Review
- Gold Polymer Nanomaterials: A Promising Approach for Enhanced Biomolecular Imaging.Nanotheranostics · 2024Review
- Advancements and Challenges in the Application of Metal-Organic Framework (MOF) Nanocomposites for Tumor Diagnosis and Treatment.International journal of nanomedicine · 2024Review
- Biocidal and synergistic effect of three types of biologically synthesised silver/silver chloride nanoparticles.World journal of microbiology & biotechnology · 2023Article
- Microenvironment Restruction of Emerging 2D Materials and their Roles in Therapeutic and Diagnostic Nano-Bio-Platforms.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Adsorption Behavior of a Gd-Based Metal-Organic Framework toward the Quercetin Drug: Effect of the Activation Condition.ACS omega · 2022Article
- Polyacrylic Acid Nanoplatforms: Antimicrobial, Tissue Engineering, and Cancer Theranostic Applications.Polymers · 2022Review
- Recent progress in the applications of gold-based nanoparticles towards tumor-targeted imaging and therapy.RSC advances · 2022Review
- Metal-Organic Frameworks for Bioimaging: Strategies and Challenges.Nanotheranostics · 2022Review
- Recent advances in porous nanostructures for cancer theranostics.Nano today · 2021Article
- Recent advances in nanosized metal organic frameworks for drug delivery and tumor therapy.RSC advances · 2021Review
- Nanoscale Metal-Organic Frameworks and Their Nanomedicine Applications.Frontiers in chemistry · 2021Review
- Review
- Applications of nanoparticles in biomedical imaging.Nanoscale · 2019Review
- Hydration number: crucial role in nuclear magnetic relaxivity of Gd(III) chelate-based nanoparticles.Scientific reports · 2017Article
- Opportunities for new CT contrast agents to maximize the diagnostic potential of emerging spectral CT technologies.Advanced drug delivery reviews · 2017Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Imaging contrast agents for magnetic resonance imaging (MRI) and computed tomography (CT) have received significant attention in the development of techniques for early stage cancer diagnosis. Gadolinium (Gd)(III), which has seven unpaired electrons and a large magnetic moment, can dramatically influence the water proton relaxation and hence exhibits excellent MRI contrast. On the other hand, gold (Au), which has a high atomic number and high X-ray attenuation coefficient, is an ideal contrast agent candidate for X-ray-based CT imaging. Gd metal-organic framework (MOF) nanoparticles with tunable size, high Gd(III) loading and multivalency can potentially overcome the limitations of clinically utilized Gd chelate contrast agents. In this work, we report for the first time the integration of GdMOF nanoparticles with gold nanoparticles (AuNPs) for the preparation of a MRI/CT bimodal imaging agent. Highly stable hybrid GdMOF/AuNPs composites have been prepared by using poly(acrylic acid) as a bridge between the GdMOF nanoparticles and AuNPs. The hybrid nanocomposites were then evaluated in MRI and CT imaging. The results revealed high longitudinal relaxivity in MRI and excellent CT imaging performance. Therefore, these GdMOF/AuNPs hybrid nanocomposites potentially provide a new platform for the development of multimodal imaging probes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.