ArticlePLoS pathogens2015
Calprotectin Increases the Activity of the SaeRS Two Component System and Murine Mortality during Staphylococcus aureus Infections.
Article in PLoS pathogens, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 67 citations in OpenAlex.
- Article
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- Treatment ofAntimicrobial agents and chemotherapy · 2025Article
- Linking Virulence and Iron Limitation Response inJournal of proteome research · 2025Article
- Human neutrophil defensin-1 binding increases histidine kinase activity of SaeS inBiochemistry and biophysics reports · 2025Article
- AACS synthetic biology · 2025Article
- Adaptive Resistance ofMicroorganisms · 2025Article
- Iron Sequestration by Murine Calprotectin Induces Starvation Responses inACS infectious diseases · 2024Article
- Temporal modelling of the biofilm lifecycle (TMBL) establishes kinetic analysis of plate-based bacterial biofilm dynamics.Journal of microbiological methods · 2023Article
- SarS Is a Repressor of Staphylococcus aureus Bicomponent Pore-Forming Leukocidins.Infection and immunity · 2023Article
- HowInternational journal of molecular sciences · 2023Review
- Analysis of the Presence of the Virulence and Regulation Genes fromInternational journal of environmental research and public health · 2023Article
- Identification of an antivirulence agent targeting the master regulator of virulence genes inFrontiers in cellular and infection microbiology · 2023Article
- A genetic regulatory see-saw of biofilm and virulence in MRSA pathogenesis.Frontiers in microbiology · 2023Review
- Gene expression ofFrontiers in microbiology · 2023Article
- A Review of Biofilm Formation ofAntibiotics (Basel, Switzerland) · 2022Review
- The influenza-injured lung microenvironment promotes MRSA virulence, contributing to severe secondary bacterial pneumonia.Cell reports · 2022Article
- PurN Is Involved in Antibiotic Tolerance and Virulence inAntibiotics (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
Calprotectin, the most abundant cytoplasmic protein in neutrophils, suppresses the growth of Staphylococcus aureus by sequestering the nutrient metal ions Zn and Mn. Here we show that calprotectin can also enhance the activity of the SaeRS two component system (TCS), a signaling system essential for production of over 20 virulence factors in S. aureus. The activity of the SaeRS TCS is repressed by certain divalent ions found in blood or neutrophil granules; however, the Zn bound-form of calprotectin relieves this repression. During staphylococcal encounter with murine neutrophils or staphylococcal infection of the murine peritoneal cavity, calprotectin increases the activity of the SaeRS TCS as well as the production of proinflammatory cytokines such as IL-1β and TNF-α, resulting in higher murine mortality. These results suggest that, under certain conditions, calprotectin can be exploited by S. aureus to increase bacterial virulence and host mortality.
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