ArticlePloS one2015
Changes in Serum Levels of Myokines and Wnt-Antagonists after an Ultramarathon Race.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- Circulating sclerostin is not suppressed following a single bout of exercise in young men.Physiological reports · 2018Trial
- Trial
- Trial
- Effects of elastic band resistance training and nutritional supplementation on muscle quality and circulating muscle growth and degradation factors of institutionalized elderly women: the Vienna Active Ageing Study (VAAS).European journal of applied physiology · 2016Trial
- Sclerostin's role in bone-muscle crosstalk and osteoporosis pathogenesis.Osteoporosis and sarcopenia · 2025Review
- Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair.Bioactive materials · 2023Article
- Contribution of Solid Food to Achieve Individual Nutritional Requirement during a Continuous 438 km Mountain Ultramarathon in Female Athlete.International journal of environmental research and public health · 2021Article
- Effects of marathon race on selected myokines and sclerostin in middle-aged male amateur runners.Scientific reports · 2021Article
- Effect of Various Exercise Regimens on Selected Exercise-Induced Cytokines in Healthy People.International journal of environmental research and public health · 2021Review
- The Consequences of Training and Competition to the Musculoskeletal System in Ultramarathon Runners: A Narrative Review.Frontiers in physiology · 2021Review
- Myostatin as a Biomarker of Muscle Wasting and other Pathologies-State of the Art and Knowledge Gaps.Nutrients · 2020Review
- Romosozumab: a novel bone anabolic treatment option for osteoporosis?Wiener medizinische Wochenschrift (1946) · 2020Article
- Hepatokines-a novel group of exercise factors.Pflugers Archiv : European journal of physiology · 2019Review
- Myostatin and other musculoskeletal markers in lung transplant recipients.Clinical and experimental medicine · 2019Article
- Physical Activity and Bone Health: What Is the Role of Immune System? A Narrative Review of the Third Way.Frontiers in endocrinology · 2019Review
- Physiology of Activins/Follistatins: Associations With Metabolic and Anthropometric Variables and Response to Exercise.The Journal of clinical endocrinology and metabolism · 2018Article
- Bone adaptation in response to treadmill exercise in young and adult mice.Bone reports · 2018Article
- Article
- Bone turnover response is linked to both acute and established metabolic changes in ultra-marathon runners.Endocrine · 2017Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRegular physical activities have a positive effect on the muscular skeletal system but overstrenuous exercise may be different. Transiently suppressed bone formation and increased bone resorption after participation in a 246-km ultradistance race has been demonstrated. PURPOSE: The aim of this study was to analyze effects of the Spartathlon race on novel musculoskeletal markers.
methodsVenous blood samples were obtained before and immediately after the race from 19 participants of the Spartathlon. From 9 runners who were available 3 days after the start blood was drawn for a third time. Serum levels of myostatin, an inhibitor of myogenic differentiation, and its opponent follistatin as well as sclerostin and dickkopf-1, both of them inhibitors of the wnt signaling pathway, and markers of bone turnover were determined.
resultsSerum levels of myostatin were significantly higher after the race. Serum follistatin only showed a transient increase. Sclerostin levels did not significantly differ before and after the race, whereas dickkopf-1 levels were significantly decreased. At follow-up a decrement of sclerostin and dickkopf-1 levels was seen. Serum cathepsin K levels did not change.
conclusionThe increase of serum levels of myostatin appears to reflect muscle catabolic processes induced by overstrenuous exercise. After the short-term uncoupling of bone turnover participation in an ultradistance race seems to initiate a long-term positive effect on bone indicated by the low-level inhibition of the Wnt/β-catenin signaling pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.