ArticleJournal of occupational and environmental medicine2015
Formaldehyde Exposure and Mortality Risks From Acute Myeloid Leukemia and Other Lymphohematopoietic Malignancies in the US National Cancer Institute Cohort Study of Workers in Formaldehyde Industries.
Article in Journal of occupational and environmental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Assessment of associations between inhaled formaldehyde and lymphohematopoietic cancer through the integration of epidemiological and toxicological evidence with biological plausibility.Toxicological sciences : an official journal of the Society of Toxicology · 2024Pooled it
- The importance of evaluating specific myeloid malignancies in epidemiological studies of environmental carcinogens.BMC cancer · 2021Pooled it
- Occupational exposure to formaldehyde and risk of non hodgkin lymphoma: a meta-analysis.BMC cancer · 2019Pooled it
- An AI assistant for critically assessing and synthesizing clusters of journal articles.Global epidemiology · 2025Article
- Occupational exposure to formaldehyde and risk of lymphoma subtypes: results of a multicentre Italian case-control study.Environmental health : a global access science source · 2025Article
- A framework for evaluating less-than-lifetime exposures: advancing toxicological risk assessment for drinking water quality.Archives of toxicology · 2025Review
- Health effects of low-dose formaldehyde exposure: a cross-sectional study in occupational settings.International journal of occupational medicine and environmental health · 2025Article
- Global, regional, and national burden of acute myeloid leukemia, 1990-2021: a systematic analysis for the global burden of disease study 2021.Biomarker research · 2024Article
- Triangulation of epidemiological evidence and risk of bias evaluation: A proposed framework and applied example using formaldehyde exposure and risk of myeloid leukemias.Global epidemiology · 2024Article
- Ambient formaldehyde and mortality: A time series analysis in China.Science advances · 2022Article
- The hazardous effects of formalin and alcoholic fixative in mice: A public health perspective study.Saudi journal of biological sciences · 2022Article
- Review
- Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2021Review
- Oxidative damage, inflammation, genotoxic effect, and global DNA methylation caused by inhalation of formaldehyde and the purpose of melatonin.Toxicology research · 2020Article
- Extended Analysis and Evidence Integration of Chloroprene as a Human Carcinogen.Risk analysis : an official publication of the Society for Risk Analysis · 2020Review
- Peak Inhalation Exposure Metrics Used in Occupational Epidemiologic and Exposure Studies.Frontiers in public health · 2020Review
- Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature.Medicina (Kaunas, Lithuania) · 2019Review
- Peak Exposures in Epidemiologic Studies and Cancer Risks: Considerations for Regulatory Risk Assessment.Risk analysis : an official publication of the Society for Risk Analysis · 2019Review
- Does formaldehyde have a causal association with nasopharyngeal cancer and leukaemia?Annals of occupational and environmental medicine · 2018Article
- Re-evaluation of the WHO (2010) formaldehyde indoor air quality guideline for cancer risk assessment.Archives of toxicology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate associations between cumulative and peak formaldehyde exposure and mortality from acute myeloid leukemia (AML) and other lymphohematopoietic malignancies.
methodsCox proportional hazards analyses.
resultsAcute myeloid leukemia was unrelated to cumulative exposure. Hodgkin lymphoma relative risk estimates in the highest exposure categories of cumulative and peak exposures were, respectively, 3.76 (Ptrend = 0.05) and 5.13 (Ptrend = 0.003). There were suggestive associations with peak exposure observed for chronic myeloid leukemia, albeit based on very small numbers. No other lymphohematopoietic malignancy was associated with either chronic or peak exposure.
conclusionsInsofar as there is no prior epidemiologic evidence supporting associations between formaldehyde and either Hodgkin leukemia or chronic myeloid leukemia, any causal interpretations of the observed risk patterns are at most tentative. Findings from this re-analysis do not support the hypothesis that formaldehyde is a cause of AML.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.