Trial reportPloS one2015
Stronger Neural Modulation by Visual Motion Intensity in Autism Spectrum Disorders.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Global Motion Perception in Autism Spectrum Disorder: A Meta-Analysis.Journal of autism and developmental disorders · 2019Pooled it
- Global motion processing in infants' visual cortex and the emergence of autism.Communications biology · 2023Article
- Reduced gamma oscillation during visual processing of the mother's face in children with autism spectrum disorder: A pilot study.PCN reports : psychiatry and clinical neurosciences · 2023Article
- Internal noise measures in coarse and fine motion direction discrimination tasks and the correlation with autism traits.Journal of vision · 2022Article
- Alterations of Regional Homogeneity in Preschool Boys With Autism Spectrum Disorders.Frontiers in neuroscience · 2021Article
- Visual Perception in Autism Spectrum Disorder: A Review of Neuroimaging Studies.Soa--ch'ongsonyon chongsin uihak = Journal of child & adolescent psychiatry · 2020Article
- Altered neural oscillations and connectivity in the beta band underlie detail-oriented visual processing in autism.NeuroImage. Clinical · 2020Article
- Dysregulated oscillatory connectivity in the visual system in autism spectrum disorder.Brain : a journal of neurology · 2019Article
- Neuronal gain modulability is determined by dendritic morphology: A computational optogenetic study.PLoS computational biology · 2018Article
- Do different experimental tasks affect psychophysical measurements of motion perception in autism-spectrum disorder? An analysis.Clinical optometry · 2018Review
- Sensory perception in autism.Nature reviews. Neuroscience · 2017Review
- Gamma-Band Activities in Mouse Frontal and Visual Cortex Induced by Coherent Dot Motion.Scientific reports · 2017Article
- Altered Onset Response Dynamics in Somatosensory Processing in Autism Spectrum Disorder.Frontiers in neuroscience · 2016Article
- Correction: Stronger Neural Modulation by Visual Motion Intensity in Autism Spectrum Disorders.PloS one · 2015Article
- Sensory sensitivity and visual discomfort are not associated with altered gamma oscillations: A test of the excitation-inhibition hypothesis.Imaging neuroscience (Cambridge, Mass.)Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Theories of autism spectrum disorders (ASD) have focused on altered perceptual integration of sensory features as a possible core deficit. Yet, there is little understanding of the neuronal processing of elementary sensory features in ASD. For typically developed individuals, we previously established a direct link between frequency-specific neural activity and the intensity of a specific sensory feature: Gamma-band activity in the visual cortex increased approximately linearly with the strength of visual motion. Using magnetoencephalography (MEG), we investigated whether in individuals with ASD neural activity reflect the coherence, and thus intensity, of visual motion in a similar fashion. Thirteen adult participants with ASD and 14 control participants performed a motion direction discrimination task with increasing levels of motion coherence. A polynomial regression analysis revealed that gamma-band power increased significantly stronger with motion coherence in ASD compared to controls, suggesting excessive visual activation with increasing stimulus intensity originating from motion-responsive visual areas V3, V6 and hMT/V5. Enhanced neural responses with increasing stimulus intensity suggest an enhanced response gain in ASD. Response gain is controlled by excitatory-inhibitory interactions, which also drive high-frequency oscillations in the gamma-band. Thus, our data suggest that a disturbed excitatory-inhibitory balance underlies enhanced neural responses to coherent motion in ASD.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.