Evidence map›Paper›PMID 26146824›Full record

ArticlePloS one2015

Knowledge, Beliefs and Practices Regarding Antiretroviral Medications for HIV Prevention: Results from a Survey of Healthcare Providers in New England.

Douglas S Krakower, Catherine E Oldenburg, Jennifer A Mitty, Ira B Wilson, Ann E Kurth, Kevin M Maloney, Donna Gallagher, Kenneth H Mayer

Abstract read
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Douglas S KrakowerDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America; The Fenway Institute, Boston, Massachusetts, United States of America.
Catherine E OldenburgHarvard School of Public Health, Boston, Massachusetts, United States of America.
Jennifer A MittyDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America.
Ira B WilsonBrown University School of Public Health, Providence, Rhode Island, United States of America.
Ann E KurthNew York University, New York, New York, United States of America.
Kevin M MaloneyDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, United States of America.
Donna GallagherNew England AIDS Education and Training Center, Boston, Massachusetts, United States of America.
Kenneth H MayerDivision of Infectious Diseases, Beth Israel Deaconess Medical Center, Boston, MA, United States of America; Harvard Medical School, Boston, Massachusetts, United States of America; The Fenway Institute, Boston, Massachusetts, United States of America; Harvard School of Public Health, Boston, Massachusetts, United States of America.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI ROBERT A. PARKER · 2004 to 2026
$94.4M
Translational ScienceP30AI042853 · NIAID · MIRIAM HOSPITAL · PI LARRY K BROWN · 1998 to 2026
$51.7M
HIV and Other Infectious Consequences of Substance UseT32DA013911 · NIDA · MIRIAM HOSPITAL · PI TRACI C GREEN, JOSIAH D RICH · 2001 to 2026
$9.6M
Epidemiology of Infectious Diseases and BiodefenseT32AI007535 · NIAID · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI GRAD, YONATAN H, MURRAY, MEGAN B · 1998 to 2025
$4.8M
The Brown Initiative in HIV and AIDS Clinical Research for Minority CommunitiesR25MH083620 · NIMH · MIRIAM HOSPITAL · PI NUNN, AMY STEWART · 2008 to 2025
$3.7M
Improving the diagnosis and treatment of medication adherence problems in HIVK24MH092242 · NIMH · BROWN UNIVERSITY · PI WILSON, IRA B · 2010 to 2014
$937k
Optimizing HIV Pre-Exposure Prophylaxis through Shared Decision MakingK23MH098795 · NIMH · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KRAKOWER, DOUGLAS SCOTT · 2012 to 2016
$873k
NIAID NIH HHS P30 AI042853NIAID NIH HHS P30 AI060354NIAID NIH HHS T32 AI007535NIDA NIH HHS T32DA0131911NIDA NIH HHS T32 DA013911NIMH NIH HHS K23 MH098795NIMH NIH HHS K24 MH092242NIMH NIH HHS R25 MH083620
6 · The paper itself

Abstract

backgroundAntiretroviral treatment for HIV-infection before immunologic decline (early ART) and pre-exposure chemoprophylaxis (PrEP) can prevent HIV transmission, but routine adoption of these practices by clinicians has been limited.

methodsBetween September and December 2013, healthcare practitioners affiliated with a regional AIDS Education and Training Center in New England were invited to complete online surveys assessing knowledge, beliefs and practices regarding early ART and PrEP. Multivariable models were utilized to determine characteristics associated with prescribing intentions and practices.

resultsSurveys were completed by 184 practitioners. Respondent median age was 44 years, 58% were female, and 82% were white. Among ART-prescribing clinicians (61% of the entire sample), 64% were aware that HIV treatment guidelines from the Department of Health and Human Services recommended early ART, and 69% indicated they would prescribe ART to all HIV-infected patients irrespective of immunologic status. However, 77% of ART-prescribing clinicians would defer ART for patients not ready to initiate treatment. Three-fourths of all respondents were aware of guidance from the U.S. Centers for Disease Control and Prevention recommending PrEP provision, 19% had prescribed PrEP, and 58% of clinicians who had not prescribed PrEP anticipated future prescribing. Practitioners expressed theoretical concerns and perceived practical barriers to prescribing early ART and PrEP. Clinicians with higher percentages of HIV-infected patients (aOR 1.16 per 10% increase in proportion of patients with HIV-infection, 95% CI 1.01-1.34) and infectious diseases specialists (versus primary care physicians; aOR 3.32, 95% CI 0.98-11.2) were more likely to report intentions to prescribe early ART. Higher percentage of HIV-infected patients was also associated with having prescribed PrEP (aOR 1.19, 95% CI 1.06-1.34), whereas female gender (aOR 0.26, 95% CI 0.10-0.71) was associated with having not prescribed PrEP.

conclusionsThese findings suggest many clinicians have shifted towards routinely recommending early ART, but not PrEP, so interventions to facilitate PrEP provision are needed.

Indexed as

Attitude of Health PersonnelHealth Knowledge, Attitudes, PracticeAdultAnti-HIV AgentsCultureFemaleHealth PersonnelHealth SurveysHIV InfectionsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisNew EnglandPhysicians, Primary CareAnti-HIV Agents

Identifiers

PMID26146824
PMCPMC4492498

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.