Evidence map›Paper›PMID 26146660›Full record

ArticleTransplantation direct2015

MYROIDES INFECTION IN A BABOON AFTER PROLONGED PIG KIDNEY GRAFT SURVIVAL.

Hong Liu, Hayato Iwase, Martin Wijkstrom, Jagjit Singh, Edwin Klein, Robert Wagner, Abhinav Humar, William Pasculle, David K C Cooper

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transplantation direct, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hong LiuThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, USA ; Department of General Surgery, First Hospital of Shanxi Medical University, Taiyuan, China.
Hayato IwaseThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, USA.
Martin WijkstromThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, USA.
Jagjit SinghThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, USA.
Edwin KleinDivision of Laboratory Animal Resources, University of Pittsburgh, PA, USA.
Robert WagnerDivision of Laboratory Animal Resources, University of Pittsburgh, PA, USA.
Abhinav HumarThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, USA.
William PasculleDepartment of Microbiology, University of Pittsburgh, Pittsburgh, USA.
David K C CooperThomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, USA.

Funding

Prolonging life-supported pig kidney and heart graft survival in baboons by suppressing inflammationU19AI090959 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, DAVID KC · 2010 to 2024
$26.3M
CORE--BABOON RESEARCH RESOURCE PROGRAMP40RR012317 · NCRR · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI WHITE, GARY L · 1998 to 2011
$13.0M
Thromboregulation to Prevent Thrombotic MicroangiopathyU01AI068642 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, DAVID KC · 2005 to 2008
$2.7M
Tolerance to Carbohydrate Antigens in TransplantationR21AI074844 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, DAVID KC · 2007 to 2008
$405k
NCRR NIH HHS P40 RR012317NIAID NIH HHS HHSN272200900037CNIAID NIH HHS R21 AI074844NIAID NIH HHS U01 AI068642NIAID NIH HHS U19 AI090959
6 · The paper itself

Abstract

backgroundImmunosuppressed patients and experimental nonhuman primates are at risk of opportunistic infection. We report a CASE REPORT: The baboon received a costimulation blockade-based immunosuppressive regimen as well as two anti-inflammatory agents (tocilizumab and etanercept). Although the pig kidney functioned well, approximately four months after the transplant the baboon became less active and ate and drank poorly. On day 136, it collapsed and died despite inotropic and fluid support. A blood culture drawn before death grew DISCUSSION AND

conclusionsTo our knowledge,

Indexed as

Anti-IL-6R antagonistCostimulation blockadeMyroides sppXenotransplantation

Identifiers

PMID26146660
PMCPMC4486305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.