Evidence map›Paper›PMID 26146646›Full record

ArticleJournal of biological methods

In vitro and in vivo model systems used in prostate cancer research.

David Cunningham, Zongbing You

Abstract read
In one paragraph

Article in Journal of biological methods. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 129 papers.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

129 citing papers in PubMed.

  1. Trial
  2. Article
  3. Differential Effects of a First-in-Class IKKCalcified tissue international · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Assessing Anti-Acne PotentialsCurrent drug targets · 2025
    Review
  16. Frontiers in physiology · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Review

69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

David CunninghamDepartment of Structural & Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA, USA.
Zongbing YouDepartment of Structural & Cellular Biology, Tulane University Health Sciences Center, New Orleans, LA, USA ; Department of Orthopaedic Surgery, Tulane University Health Sciences Center, New Orleans, LA, USA ; Tulane Cancer Center and Louisiana Cancer Research Consortium, Tulane University Health Sciences Center, New Orleans, LA, USA ; Tulane Center for Stem Cell Research and Regenerative Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA ; Tulane Center for Aging, Tulane University Health Sciences Center, New Orleans, LA, USA.

Funding

UNCOVERING THE MECHANISMS OF OSTEOSARCOMA METASTASIS SUPPRESSION BY MTBPP20RR020152 · NCRR · TULANE UNIVERSITY OF LOUISIANA · PI FORTGANG, ILANA · 2004 to 2011
$17.0M
Mentoring a Cancer Genetics ProgramP20GM103518 · NIGMS · TULANE UNIVERSITY OF LOUISIANA · PI DEININGER, PRESCOTT L. · 2012 to 2013
$4.3M
The role of IL-17 in prostate cancerR01CA174714 · NCI · TULANE UNIVERSITY OF LOUISIANA · PI YOU, ZONGBING · 2013 to 2017
$1.6M
NCI NIH HHS R01 CA174714NCRR NIH HHS P20 RR020152NIGMS NIH HHS P20 GM103518
6 · The paper itself

Abstract

New incidence of prostate cancer is a major public health issue in the Western world, and has been rising in other areas of the globe in recent years. In an effort to understanding the molecular pathogenesis of this disease, numerous cell models have been developed, arising mostly from patient biopsies. The introduction of the genetically engineered mouse in biomedical research has allowed the development of murine models that allow for the investigation of tumorigenic and metastatic processes. Current challenges to the field include lack of an animal model that faithfully recapitulates bone metastasis of prostate cancer.

Indexed as

cell linesintratibial injectionmouse modelsprostate cancerxenograft

Identifiers

PMID26146646
PMCPMC4487886

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.