Evidence map›Paper›PMID 26146550›Full record

ArticleBiomaterials science2015

Shape Control in Engineering of Polymeric Nanoparticles for Therapeutic Delivery.

John-Michael Williford, Jose Luis Santos, Rishab Shyam, Hai-Quan Mao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Review
  2. How Key in vivo Models Can Advance Anticancer Nanotherapeutics.International journal of nanomedicine · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

John-Michael WillifordDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 ; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218 ; Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD 21287.
Jose Luis SantosInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218 ; Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD 21287 ; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218.
Rishab ShyamDepartment of Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, Maryland 21205 ; Institute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218 ; Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD 21287.
Hai-Quan MaoInstitute for NanoBioTechnology, Johns Hopkins University, Baltimore, Maryland 21218 ; Translational Tissue Engineering Center, Johns Hopkins School of Medicine, Baltimore, MD 21287 ; Department of Materials Science and Engineering, Johns Hopkins University, Baltimore, MD 21218 ; Whitaker Biomedical Engineering Institute, Johns Hopkins University, Baltimore, MD 21218.

Funding

ValidationU54CA151838 · NCI · JOHNS HOPKINS UNIVERSITY · PI MAITRA, ANIRBAN · 2010 to 2014
$11.9M
Shape Control and Transport Properties of DNA-Copolymer MicellesR01EB018358 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI LUIJTEN, ERIK, MAO, HAI-QUAN · 2015 to 2018
$2.1M
Delivery of Shaped siRNA Nanoparticles by Retrograde Intrabiliary InfusionR21EB015152 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MAO, HAI-QUAN · 2012 to 2013
$437k
Shape Control and Transfection of Self-assembled Polymer-DNA NanoparticlesR21EB013274 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI MAO, HAI-QUAN · 2012 to 2013
$431k
NCI NIH HHS U54 CA151838NCI NIH HHS U54CA151838NIBIB NIH HHS R01 EB018358NIBIB NIH HHS R21 EB013274NIBIB NIH HHS R21EB013274NIBIB NIH HHS R21 EB015152NIBIB NIH HHS R21EB015152
6 · The paper itself

Abstract

Nanoparticle-mediated delivery of therapeutics holds great potential for the diagnosis and treatment of a wide range of diseases. Significant advances have been made in the design of new polymeric nanoparticle carriers through modulation of their physical and chemical structures and biophysical properties. Nanoparticle shape has been increasingly proposed as an important attribute dictating their transport properties in biological milieu. In this review, we highlight three major methods for preparing polymeric nanoparticles that allow for exquisite control of particle shape. Special attention is given to various approaches to controlling nanoparticle shape by tuning copolymer structural parameters and assembly conditions. This review also provides comparisons of these methods in terms of their unique capabilities, materials choices, and specific delivery cargos, and summarizes the biological effects of nanoparticle shape on transport properties at the tissue and cellular levels.

Indexed as

Drug CarriersDrug Delivery SystemsDrug DesignHumansNanoparticlesPolymersDrug CarriersPolymersdrug deliverygene therapypolymeric nanoparticlesshape control

Identifiers

PMID26146550
PMCPMC4486355

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.