Evidence map›Paper›PMID 26146549›Full record

ArticleBiomaterials science2015

Elastin-based biomaterials and mesenchymal stem cells.

Jazmin Ozsvar, Suzanne M Mithieux, Richard Wang, Anthony S Weiss

Open access · greenAbstract read
In one paragraph

Article in Biomaterials science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 54 citations in OpenAlex.

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  11. Elastic proteins and elastomeric protein alloys.Current opinion in biotechnology · 2016
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Jazmin OzsvarSchool of Molecular Bioscience, The University of Sydney, NSW 2006, Australia ; Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.
Suzanne M MithieuxSchool of Molecular Bioscience, The University of Sydney, NSW 2006, Australia ; Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.
Richard WangSchool of Molecular Bioscience, The University of Sydney, NSW 2006, Australia ; Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.
Anthony S WeissSchool of Molecular Bioscience, The University of Sydney, NSW 2006, Australia ; Charles Perkins Centre, The University of Sydney, NSW 2006, Australia.
Harry Perkins Institute of Medical Research · AUUniversity of Sydney · AU

Funding

Multifunctional Tropoelastin-Silk Biomaterial SystemsR01EB014283 · NIBIB · TUFTS UNIVERSITY MEDFORD · PI KAPLAN, DAVID L. · 2012 to 2015
$1.2M
NIBIB NIH HHS EB014283NIBIB NIH HHS R01 EB014283
6 · The paper itself

Abstract

Elastin is the dominant mammalian elastic protein found in soft tissue. Elastin-based biomaterials have the potential to repair elastic tissues by improving local elasticity and providing appropriate cellular interactions and signaling. Studies that combine these biomaterials with mesenchymal stem cells have demonstrated their capacity to also regenerate non-elastic tissue. Mesenchymal stem cell differentiation can be controlled by their immediate environment, and their sensitivity to elasticity makes them an ideal candidate for combining with elastin-based biomaterials. With the growing accessibility of the elastin precursor, tropoelastin, and elastin-derived materials, the amount of research interest in combining these two fields has increased and, subsequently, is leading to the realization of a potentially new strategy for regenerative medicine.

Indexed as

AnimalsBiocompatible MaterialsCell DifferentiationElastic TissueElastinHumansMesenchymal Stem CellsBiocompatible MaterialsElastin

Identifiers

PMID26146549
PMCPMC4486348
OpenAlexW2045698768

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.