Evidence map›Paper›PMID 26146535›Full record

ArticleChemical science2014

Thiosquaramides: pH switchable anion transporters.

Nathalie Busschaert, Robert B P Elmes, Dawid D Czech, Xin Wu, Isabelle L Kirby, Evan M Peck, Kevin D Hendzel, Scott K Shaw, Bun Chan, Bradley D Smith and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Chemical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 151 citations in OpenAlex.

  1. Article
  2. Article
  3. Hemi-Indigiosin: A pH and Red-Light Responsive Transmembrane HCl Transporter.Angewandte Chemie (International ed. in English) · 2025
    Article
  4. Review
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  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Carbazole-Based Colorimetric Anion Sensors.Molecules (Basel, Switzerland) · 2021
    Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Nathalie BusschaertChemistry, University of Southampton, Southampton, SO17 1BJ, UK.
Robert B P ElmesSchool of Chemistry (F11), The University of Sydney, 2006 NSW, Australia.
Dawid D CzechChemistry, University of Southampton, Southampton, SO17 1BJ, UK.
Xin WuChemistry, University of Southampton, Southampton, SO17 1BJ, UK.
Isabelle L KirbyChemistry, University of Southampton, Southampton, SO17 1BJ, UK.
Evan M PeckDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, 46556, USA.
Kevin D HendzelDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, 46556, USA.
Scott K ShawDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, 46556, USA.
Bun ChanSchool of Chemistry (F11), The University of Sydney, 2006 NSW, Australia.
Bradley D SmithDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, 46556, USA.
Katrina A JolliffeSchool of Chemistry (F11), The University of Sydney, 2006 NSW, Australia.
Philip A GaleChemistry, University of Southampton, Southampton, SO17 1BJ, UK ; Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
University of Notre Dame · USUniversity of Southampton · GBUniversity of Sydney · AUKing Abdulaziz University · SA

Funding

PROMOTERS AND INHIBITORS OF MEMBRANE FUSIONR01GM059078 · NIGMS · UNIVERSITY OF NOTRE DAME · PI SMITH, BRADLEY D · 1999 to 2019
$5.8M
Chemistry-Biochemistry-Biology Training Program at Notre DameT32GM075762 · NIGMS · UNIVERSITY OF NOTRE DAME · PI CHANG, MAYLAND F, MOBASHERY, SHAHRIAR · 2007 to 2021
$3.7M
NIGMS NIH HHS R01 GM059078NIGMS NIH HHS T32 GM075762
6 · The paper itself

Abstract

The transport of anions across cellular membranes is an important biological function governed by specialised proteins. In recent years, many small molecules have emerged that mimick the anion transport behaviour of these proteins, but only a few of these synthetic molecules also display the gating/switching behaviour seen in biological systems. A small series of thiosquaramides was synthesised and their pH-dependent chloride binding and anion transport behaviour was investigated using

Identifiers

PMID26146535
PMCPMC4486358
OpenAlexW2145179157

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.