ArticleThyroid research2015
Iodine intake as a risk factor for thyroid cancer: a comprehensive review of animal and human studies.
Article in Thyroid research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
122 citing papers in PubMed, 5 syntheses or guidelines pooled it, 264 citations in OpenAlex.
- A scalable outpatient framework for BI-RADS 2-4B breast nodule management: an iodine-DMSO transdermal protocol.Frontiers in health services · 2026Pooled it
- Global incidence and prevalence of differentiated thyroid cancer in childhood: systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Assessment of thyroid cancer risk in more than 334,000 patients with inflammatory bowel disease: a case-control study and a meta-analysis.World journal of surgical oncology · 2018Pooled it
- Coffee Consumption and the Risk of Thyroid Cancer: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2017Pooled it
- Dietary and Urinary Iodine in Relation to Thyroid Cancer Risk: A Meta-Analysis.Cancer control : journal of the Moffitt Cancer CenterPooled it
- Article
- Early Birds and Thyroid Cancer: Unveiling the Link Between Morningness and Thyroid Cancer Risk Through Mendelian Randomization.Brain and behavior · 2026Article
- The critical role of ferroptosis in thyroid cancer development and potential therapeutic implications.Frontiers in oncology · 2026Review
- Perithyroidal Adipose Tissue Drives Thyroid Tumorigenesis through Adipokine Signaling and Immune Suppression.Research (Washington, D.C.) · 2026Article
- Hashimoto's thyroiditis both promotes and protects against papillary thyroid cancer.Frontiers in endocrinology · 2026Review
- Unravelling the rise in thyroid cancer incidence and addressing overdiagnosis.Nature reviews. Endocrinology · 2026Review
- CatBoost with physics-based metaheuristics for thyroid cancer recurrence prediction.BioData mining · 2025Article
- Effect of hysterectomy on risk of thyroid cancer and benign thyroid disorders in South Korean women.Scientific reports · 2025Article
- Article
- Epidemiology of thyroid cancer in Asia in 2020 and its projection to 2040.BMC public health · 2025Article
- Fusion genes in cancers: Biogenesis, functions, and therapeutic implications.Genes & diseases · 2025Review
- Spatial heterogeneity and temporal trends of thyroid cancer incidence in Iran from 2014 to 2017.Scientific reports · 2025Article
- Review
- Continued rise in the incidence of thyroid cancer in Iran: true increase or overdiagnosis?Journal of diabetes and metabolic disorders · 2025Article
- In-utero and newborn factors and thyroid cancer incidence in adult women in the Sister Study cohort.British journal of cancer · 2025Observational
62 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Thyroid cancer (TC) is the most common endocrine malignancy and in most countries, incidence rates are increasing. Although differences in population iodine intake are a determinant of benign thyroid disorders, the role of iodine intake in TC remains uncertain. We review the evidence linking iodine intake and TC from animal studies, ecological studies of iodine intake and differentiated and undifferentiated TC, iodine intake and mortality from TC and occult TC at autopsy, as well as the case-control and cohort studies of TC and intake of seafood and milk products. We perform a new meta-analysis of pooled measures of effect from case-control studies of total iodine intake and TC. Finally, we examine the post-Chernobyl studies linking iodine status and risk of TC after radiation exposure. The available evidence suggests iodine deficiency is a risk factor for TC, particularly for follicular TC and possibly, for anaplastic TC. This conclusion is based on: a) consistent data showing an increase in TC (mainly follicular) in iodine deficient animals; b) a plausible mechanism (chronic TSH stimulation induced by iodine deficiency); c) consistent data from before and after studies of iodine prophylaxis showing a decrease in follicular TC and anaplastic TC; d) the indirect association between changes in iodine intake and TC mortality in the decade from 2000 to 2010; e) the autopsy studies of occult TC showing higher microcarcinoma rates with lower iodine intakes; and f) the case control studies suggesting lower risk of TC with higher total iodine intakes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.