ArticleCell reports2015
Sensory-Evoked Intrinsic Imaging Signals in the Olfactory Bulb Are Independent of Neurovascular Coupling.
Article in Cell reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Factors Contributing to Resistance to Ischemia-Reperfusion Injury in Olfactory Mitral Cells.International journal of molecular sciences · 2025Review
- Optimized laser speckle-based imaging system and methods for deep tissue cerebral blood flow imaging in small rodents.Neurophotonics · 2025Article
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Optical Devices for the Diagnosis and Management of Spinal Cord Injuries: A Review.Biosensors · 2024Review
- Haploinsufficiency ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cranial and Spinal Window Preparation forExperimental neurobiology · 2022Review
- Article
- An increase in dendritic plateau potentials is associated with experience-dependent cortical map reorganization.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Birefringence Changes of Dendrites in Mouse Hippocampal Slices Revealed with Polarizing Microscopy.Biophysical journal · 2020Article
- Computational exploration of molecular receptive fields in the olfactory bulb reveals a glomerulus-centric chemical map.Scientific reports · 2020Article
- Detection of neural light-scattering activity in vivo: optical transmittance studies in the rat brain.NeuroImage · 2018Article
- Water apparent diffusion coefficient correlates with gamma oscillation of local field potentials in the rat brain nucleus accumbens following alcohol injection.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Modulation of water diffusion by activation-induced neural cell swelling in Aplysia Californica.Scientific reports · 2017Article
- Water diffusion closely reveals neural activity status in rat brain loci affected by anesthesia.PLoS biology · 2017Article
- Superresolution imaging reveals activity-dependent plasticity of axon morphology linked to changes in action potential conduction velocity.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Developmental Changes in Sensory-Evoked Optical Intrinsic Signals in the Rat Barrel Cortex.Frontiers in cellular neuroscience · 2017Article
- Dense encoding of natural odorants by ensembles of sparsely activated neurons in the olfactory bulb.Scientific reports · 2016Article
- Wide-field optical mapping of neural activity and brain haemodynamics: considerations and novel approaches.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Functional brain-imaging techniques used in humans and animals, such as functional MRI and intrinsic optical signal (IOS) imaging, are thought to largely rely on neurovascular coupling and hemodynamic responses. Here, taking advantage of the well-described micro-architecture of the mouse olfactory bulb, we dissected the nature of odor-evoked IOSs. Using in vivo pharmacology in transgenic mouse lines reporting activity in different cell types, we show that parenchymal IOSs are largely independent of neurotransmitter release and neurovascular coupling. Furthermore, our results suggest that odor-evoked parenchymal IOSs originate from changes in light scattering of olfactory sensory neuron axons, mostly due to water movement following action potential propagation. Our study sheds light on a direct correlate of neuronal activity, which may be used for large-scale functional brain imaging.
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Registered trials
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