Evidence map›Paper›PMID 26145984›Full record

ReviewThe Journal of allergy and clinical immunology2015

Promising candidates for allergy prevention.

James E Gern

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of allergy and clinical immunology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.3field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. The Effect ofEvidence-based complementary and alternative medicine : eCAM · 2017
    Article
  10. Subgroup differences in the associations between dog exposure during the first year of life and early life allergic outcomes.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2017
    Article
  11. The microbiome and development of allergic disease.Current opinion in allergy and clinical immunology · 2016
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

James E GernDepartments of Pediatrics and Medicine, University of Wisconsin-Madison, Madison, Wis. Electronic address: gern@medicine.wisc.edu.
University of Wisconsin–Madison · US

Funding

Inner City Asthma consortium 3 (ICAC3)UM1AI114271 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E., JACKSON, DANIEL J · 2014 to 2021
$79.4M
Virus-Bacterial Interactions and Exacerba of AsthmaP01HL070831 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI GERN, JAMES E. · 2002 to 2017
$31.3M
Wisconsin Infant Study Cohort (WISC)U19AI104317 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI Irene M Ong · 2013 to 2026
$22.5M
NHLBI NIH HHS P01 HL070831NIAID NIH HHS U19 AI104317NIAID NIH HHS U19 AI104317-02NIAID NIH HHS UM1 AI114271NIAID NIH HHS UM1 AI114271-01
6 · The paper itself

Abstract

Recent advances in understanding environmental risk factors for allergic diseases in children have led to renewed efforts aimed at prevention. Factors that modify the probability of developing allergies include prenatal exposures, mode of delivery, diet, patterns of medication use, and exposure to pets and farm animals. Recent advances in microbial detection techniques demonstrate that exposure to diverse microbial communities in early life is associated with a reduction in allergic disease. In fact, microbes and their metabolic products might be essential for normal immune development. Identification of these risk factors has provided new targets for prevention of allergic diseases, and possibilities of altering microbial exposure and colonization to reduce the incidence of allergies is a promising approach. This review examines the rationale, feasibility, and potential effect for the prevention of childhood allergic diseases and explores possible strategies for enhancing exposure to beneficial microbes.

Indexed as

DietAnimalsBacteriaChildEnvironmental ExposureFemaleHumansHypersensitivityMicrobiotaPregnancyPrenatal Exposure Delayed EffectsRiskAllergydietIgEinterventionprebioticspreventionprobiotics

Identifiers

PMID26145984
PMCPMC4493904
OpenAlexW1798233184

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.