ReviewNature reviews. Microbiology2015
A functional perspective on phenotypic heterogeneity in microorganisms.
Review in Nature reviews. Microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 496 papers.
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Who cites it
496 citing papers in PubMed.
- Bacterial strategies for surviving antibiotics during urinary tract infection: could uropathogenic Escherichia coli be persisters?Nature reviews. Urology · 2026Review
- Bridging energy and proteome allocation models allows prediction of the resource cost of traits across environments.PLoS biology · 2026Article
- Bacteriophage-bacteria coevolution: from molecular arms races to ecological and applied perspectives.Archives of microbiology · 2026Review
- Learning stochasticity via a nonparametric approach to state-dependent noise estimation.Nature communications · 2026Article
- Biofilm formation and dynamics in the marine cyanobacterium Prochlorococcus.Nature communications · 2026Article
- Article
- Ecological Stress Tolerance and Biofilm-Associated Persistence in Opportunistic Bacteria Isolated from Livestock Faeces.Pathogens (Basel, Switzerland) · 2026Article
- Comparative Genomic Analysis of Clonal Variants of aMicroorganisms · 2026Article
- A haloarchaeal VapBC toxin-antitoxin system: regulatory mechanism and role in establishing population heterogeneity to facilitate survival of subpopulations under stress conditions.Applied and environmental microbiology · 2026Article
- Perturbing H-NS function reveals roles in restricting virulence heterogeneity and pathogen adaptation.PLoS pathogens · 2026Article
- Emergent phenotypic heterogeneity in synthetic cross-feeding consortia driven by heterogeneous metabolite distribution.National science review · 2026Article
- Phenotypic heterogeneity in the human gut microbiome revealed by subspecies-resolution single-cell transcriptomics.bioRxiv : the preprint server for biology · 2026Article
- Bacterial Sentience Is Determined by the Stochastic, Chaotic, and Deterministic Behavior of Cytoplasmic Particles.Current issues in molecular biology · 2026Review
- The impact of evolutionary dynamics and expression plasmid stability on long-term heterologous protein production by yeast.Microbial cell factories · 2026Article
- Simultaneous measurements of translation rate and transcriptome uncovers linked regulation within an active bacterial cell population.Science advances · 2026Article
- Beyond Resistance Genes:Life (Basel, Switzerland) · 2026Review
- Single-bacterium RNA-seq protocol to uncover heterogeneous expression of coding and noncoding genes in Bacteroides thetaiotaomicron.STAR protocols · 2026Article
- Passage-Dependent Size Distributions of Human-Derived Cells: Implications for Metabolic Assays.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells.Nature communications · 2026Review
- Single-cell heterogeneity in ribosome levels and protein synthesis during nutrient starvation is driven by cAMP signaling.Science advances · 2026Article
436 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most microbial communities consist of a genetically diverse assembly of different organisms, and the level of genetic diversity plays an important part in community properties and functions. However, biological diversity also arises at a lower level of biological organization, between genetically identical cells that reside in the same microenvironment. In this Review, I outline the molecular mechanisms responsible for phenotypic heterogeneity and discuss how phenotypic heterogeneity allows genotypes to persist in fluctuating environments. I also describe how it promotes interactions between phenotypic subpopulations in clonal groups, providing microbial groups with new functionality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.