Evidence map›Paper›PMID 26145718›Full record

Trial reportScientific reports2015

Validation of Placebo in a Manual Therapy Randomized Controlled Trial.

Aleksander Chaibi, Jūratė Šaltytė Benth, Michael Bjørn Russell

3 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01741714 nacompletednot on this map

Is Chiropractic Spinal Manipulative Therapy an Efficient Treatment Option for Migraine? A Randomized Controlled Clinical Trial

TypeinterventionalSponsorUniversity Hospital, AkershusRan2013 to 2015Enrolled104ConditionsMigraine With Aura, Migraine Without AuraArmsSham chiropractic manipulative therapy, Chiropractic spinal manipulative therapy
NCT05374057 phase4unknown statusnot on this mapstarted 2022, after this paper: background citation

Chiropractic Spinal Manipulative Therapy for Acute Neck Pain: a 4- Arm Clinical Placebo Randomized Controlled Trial

TypeinterventionalSponsorUniversity Hospital, AkershusRan2022 to 2024Enrolled320ConditionsAcute Neck PainArmsChiropractic spinal manipulative therapy (CSMT), CSMT sham manipulation, Ibuprofen, Placebo medication
NCT06477822 nacompletednot on this mapstarted 2024, after this paper: background citation

Effect of a Sequence of Specific Manual Therapy Techniques Targeting the Autonomic Nervous System in Healthy Adults: a Single-application Double-blind Randomized Controlled Trial

TypeinterventionalSponsorUniversitat Internacional de CatalunyaRan2024 to 2026Enrolled100ConditionsAutonomic ImbalanceArmsSequence of manual therapy techniques, Simulated manual therapy techniques
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Manual Therapy Effect in Placebo-Controlled Trials: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022
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  19. Seeing the Truth About Double Blinding.Journal of general internal medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aleksander Chaibi1] Head and Neck Research Group, Research Centre, Akershus University Hospital, 1478 Lørenskog, Oslo, Norway [2] Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Oslo, Norway.
Jūratė Šaltytė Benth1] Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Oslo, Norway [2] HØKH, Research Centre, Akershus University Hospital, 1478 Lørenskog, Oslo, Norway.
Michael Bjørn Russell1] Head and Neck Research Group, Research Centre, Akershus University Hospital, 1478 Lørenskog, Oslo, Norway [2] Institute of Clinical Medicine, Akershus University Hospital, University of Oslo, 1474 Nordbyhagen, Oslo, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At present, no consensus exists among clinical and academic experts regarding an appropriate placebo for randomized controlled trials (RCTs) of spinal manipulative therapy (SMT). Therefore, we investigated whether it was possible to conduct a chiropractic manual-therapy RCT with placebo. Seventy migraineurs were randomized to a single-blinded placebo-controlled clinical trial that consisted of 12 treatment sessions over 3 months. The participants were randomized to chiropractic SMT or placebo (sham manipulation). After each session, the participants were surveyed on whether they thought they had undergone active treatment ("yes" or "no") and how strongly they believed that active treatment was received (numeric rating scale 0-10). The outcome measures included the rate of successful blinding and the certitude of the participants' beliefs in both treatment groups. At each treatment session, more than 80% of the participants believed that they had undergone active treatment, regardless of group allocation. The odds ratio for believing that active treatment was received was >10 for all treatment sessions in both groups (all p < 0.001). The blinding was maintained throughout the RCT. Our results strongly demonstrate that it is possible to conduct a single-blinded manual-therapy RCT with placebo and to maintain the blinding throughout 12 treatment sessions given over 3 months.

Indexed as

Placebo EffectAdolescentAdultAgedFemaleHeadache DisordersHumansMaleManipulation, ChiropracticMiddle AgedMusculoskeletal ManipulationsOdds RatioTreatment OutcomeValidation Studies as TopicYoung Adult

Identifiers

PMID26145718
PMCPMC4491841

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.