ArticlePlacenta2015
Influence of high fat diet and resveratrol supplementation on placental fatty acid uptake in the Japanese macaque.
Article in Placenta, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 33 citations in OpenAlex.
- Dietary Interventions Targeting Maternal Obesity: Intergenerational Effects, Mechanisms, and Translational Insights.Current nutrition reports · 2026Review
- Maternal and early life exposures and their potential to influence development of the microbiome.Genome medicine · 2022Review
- How the placenta-brain lipid axis impacts the nutritional origin of child neurodevelopmental disorders: Focus on attention deficit hyperactivity disorder and autism spectrum disorder.Experimental neurology · 2022Review
- Effects of Maternal Resveratrol Intake on the Metabolic Health of the Offspring.International journal of molecular sciences · 2021Review
- Article
- Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat.Reproductive sciences (Thousand Oaks, Calif.) · 2020Article
- Curcumin ameliorates gestational diabetes in mice partly through activating AMPK.Pharmaceutical biology · 2019Article
- Activation of AMPK in Human Placental Explants Impairs Mitochondrial Function and Cellular Metabolism.Reproductive sciences (Thousand Oaks, Calif.) · 2019Article
- Fatty acid transporter expression and regulation is impaired in placental macrovascular endothelial cells in obese women.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2019Article
- Developmental Programming of Obesity and Diabetes in Mouse, Monkey, and Man in 2018: Where Are We Headed?Diabetes · 2018Review
- Embryoid body test with morphological and molecular endpoints implicates potential developmental toxicity of trans-resveratrol.Toxicology and applied pharmacology · 2018Article
- Sex and gender differences in developmental programming of metabolism.Molecular metabolism · 2018Review
- Developmental Programming of the Metabolic Syndrome: Can We Reprogram with Resveratrol?International journal of molecular sciences · 2018Review
- High-fat diet effects on amniotic fluid volume and amnion aquaporin expression in non-human primates.Physiological reports · 2018Article
- Effect of maternal high-fat diet on key components of the placental and hepatic endocannabinoid system.American journal of physiology. Endocrinology and metabolism · 2018Article
- Effect of moderate, 30 percent global maternal nutrient reduction on fetal and postnatal baboon phenotype.Journal of medical primatology · 2017Article
- Neonatal fatty acid profiles are correlated with infant growth measures at 6 months.Journal of developmental origins of health and disease · 2017Article
- Maternal Weight Gain Regulates Omega-3 Fatty Acids in Male, Not Female, Neonates.Reproductive sciences (Thousand Oaks, Calif.) · 2017Article
- Article
- Maternal obesity and neurodevelopmental and psychiatric disorders in offspring.Prenatal diagnosis · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
introductionAdequate maternal supply and placental delivery of long chain polyunsaturated fatty acids (LCPUFA) is essential for normal fetal development. In humans, maternal obesity alters placental FA uptake, though the impact of diet remains uncertain. The fatty fetal liver observed in offspring of Japanese macaques fed a high fat diet (HFD) was prevented with resveratrol supplementation during pregnancy. We sought to determine the effect of HFD and resveratrol, a supplement with insulin-sensitizing properties, on placental LCPUFA uptake in this model.
methodsJ. macaques were fed control chow (15% fat, n = 5), HFD (35% fat, n = 10) or HFD containing 0.37% resveratrol (n = 5) prior to- and throughout pregnancy. At ∼ 130 d gestation (term = 173 d), placentas were collected by caesarean section. Fatty acid uptake studies using (14)C-labeled oleic acid, arachidonic acid (AA) and docosahexanoic acid (DHA) were performed in placental explants.
resultsResveratrol supplementation increased placental uptake of DHA (P < 0.05), while HFD alone had no measurable effect. Resveratrol increased AMP-activated protein kinase activity and mRNA expression of the fatty acid transporters FATP-4, CD36 and FABPpm (P < 0.05). Placental DHA content was decreased in HFD dams; resveratrol had no effect on tissue fatty acid profiles. DISCUSSION: Maternal HFD did not significantly affect placental LCPUFA uptake. Furthermore, resveratrol stimulated placental DHA uptake capacity, AMPK activation and transporter expression. Placental handling of DHA is particularly sensitive to the dramatic alterations in the maternal metabolic phenotype and placental AMPK activity associated with resveratrol supplementation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.