Observational studyAmerican journal of ophthalmology2015
Relationship Between Juxtapapillary Choroidal Volume and Beta-Zone Parapapillary Atrophy in Eyes With and Without Primary Open-Angle Glaucoma.
Observational study in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 47 citations in OpenAlex.
- Prevalence and diagnostic ability of β-zone parapapillary atrophy in open-angle glaucoma: a systematic review and meta-analysis.BMC ophthalmology · 2022Pooled it
- Movement of central retinal vessel trunk and its correlation with lamina cribrosa pores movement after short-term intraocular pressure elevation.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Longitudinal Changes in Choroidal Thickness Across the Eye in Young Children With Premyopia.Investigative ophthalmology & visual science · 2026Article
- Optic Nerve Head Morphology and Macula Ganglion Cell Inner Plexiform Layer Thickness in Axially Anisometropic Rhesus Monkeys.Investigative ophthalmology & visual science · 2024Article
- Short-Term Myopic Defocus and Choroidal Thickness in Children and Adults.Investigative ophthalmology & visual science · 2024Article
- Choroidal Microvasculature Dropout in the Absence of Parapapillary Atrophy in POAG.Investigative ophthalmology & visual science · 2023Article
- Beta zone parapapillary atrophy in elderly Chinese.BMC ophthalmology · 2022Article
- Predictive Modeling of Long-Term Glaucoma Progression Based on Initial Ophthalmic Data and Optic Nerve Head Characteristics.Translational vision science & technology · 2022Article
- Effects of Monocular Light Deprivation on the Diurnal Rhythms in Retinal and Choroidal Thickness.Investigative ophthalmology & visual science · 2022Article
- Characteristics of the Optic Nerve Head in Myopic Eyes Using Swept-Source Optical Coherence Tomography.Investigative ophthalmology & visual science · 2022Article
- Optic disc morphology and peripapillary atrophic changes in diabetic children and adults without diabetic retinopathy or visual impairment.Acta ophthalmologica · 2022Article
- Association of macular thickness with parapapillary atrophy in myopic eyes.BMC ophthalmology · 2020Article
- Microstructure of Nonjuxtapapillary Microvasculature Dropout in Healthy Myopic Eyes.Investigative ophthalmology & visual science · 2020Article
- Morphological features of parapapillary beta zone and gamma zone in chronic primary angle-closure glaucoma.Eye (London, England) · 2019Article
- The use of zonal analysis of peripapillary choroidal thickness in primary open-angle glaucoma.Japanese journal of ophthalmology · 2018Observational
- Assessment of peripapillary choroidal thickness in primary open-angle glaucoma patients with choroidal vascular prominence.Japanese journal of ophthalmology · 2017Article
- Article
- Factors Associated with the Retinal Nerve Fiber Layer Loss after Acute Primary Angle Closure: A Prospective EDI-OCT Study.PloS one · 2017Article
- Controversies in the association of parapapillary atrophy with glaucoma.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
purposeTo evaluate whether quantity of choroidal tissue directly adjacent to the optic nerve differs between eyes with and without glaucoma and whether beta-zone parapapillary atrophy influences this relationship.
designProspective cohort study.
methodsSubjects were enrolled in a longitudinal, observational study at our institution. We studied 1 eye of 63 primary open-angle glaucoma (POAG), 30 ocular hypertension (OH), and 48 control subjects. Using optical coherence tomography enhanced depth imaging, we acquired 12 radial scans centered on the optic nerve head with 15 degrees of separation between scans. After images were enhanced, segmented, and corrected for ocular magnification, juxtapapillary choroidal volumetric parameters were calculated using raw thickness measurements and standard interpolation techniques. Juxtapapillary choroidal volume was then compared by diagnosis and by beta-zone parapapillary atrophy status.
resultsTotal juxtapapillary choroidal volume was significantly reduced in POAG vs OH and control eyes (1.057 vs 1.228 vs 1.255 μL, P = .04) and it was reduced in eyes with vs without beta-zone parapapillary atrophy (1.076 μL, n = 80 vs 1.306 μL, n = 61, P < .001). Juxtapapillary choroidal volume did not differ between POAG, OH, and control eyes when beta-zone parapapillary atrophy was absent, but juxtapapillary choroidal volume was significantly reduced in POAG vs control eyes when beta-zone parapapillary atrophy was present (0.957 vs 1.196 μL, P = .02). Furthermore, POAG eyes with beta-zone parapapillary atrophy had substantially lower juxtapapillary choroidal volume compared to POAG eyes without beta-zone parapapillary atrophy (0.957 vs 1.356 μL, P < .001).
conclusionsThe volume of choroid adjacent to the optic nerve was significantly reduced in POAG eyes when beta-zone parapapillary atrophy was present, suggesting that beta-zone parapapillary atrophy may be a biomarker for juxtapapillary choroidal atrophy and associated vascular compromise in POAG.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.