ArticleBioorganic & medicinal chemistry letters2015
Exploration of the structure-activity relationship of 1,2,4-oxadiazole antibiotics.
Article in Bioorganic & medicinal chemistry letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Targeting SleC and CspB in the Inhibition of Spore Germination inJournal of medicinal chemistry · 2025Article
- A Potent and Narrow-Spectrum Antibacterial againstJournal of medicinal chemistry · 2023Article
- A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents.Molecular diversity · 2022Review
- Development of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract.ACS omega · 2022Article
- Synergism of a Novel 1,2,4-oxadiazole-containing Derivative with Oxacillin against Methicillin-ResistantAntibiotics (Basel, Switzerland) · 2021Article
- β-Lactams against the Fortress of the Gram-PositiveChemical reviews · 2021Review
- Unconventional Antibacterials and Adjuvants.Accounts of chemical research · 2021Article
- 3D-QSAR Studies of 1,2,4-Oxadiazole Derivatives as Sortase A Inhibitors.BioMed research international · 2021Article
- Bioactive Compounds from Marine Heterobranchs.Marine drugs · 2020Review
- Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2020Review
- 1,2,4-Oxadiazole/2-Imidazoline Hybrids: Multi-target-directed Compounds for the Treatment of Infectious Diseases and Cancer.International journal of molecular sciences · 2019Article
- Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria.Antimicrobial agents and chemotherapy · 2018Article
- Metal-free hydroarylation of the side chain carbon-carbon double bond of 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles in triflic acid.Beilstein journal of organic chemistry · 2017Article
- The oxadiazole antibacterials.Current opinion in microbiology · 2016Review
- Three-dimensional QSAR analysis and design of new 1,2,4-oxadiazole antibacterials.Bioorganic & medicinal chemistry letters · 2016Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
We have recently disclosed the discovery of the class of 1,2,4-oxadiazole antibiotics, which emerged from in silico docking and scoring efforts. This class of antibacterials exhibits Gram-positive activity, particularly against Staphylococcus aureus. We define the structure-activity relationship (SAR) of this class of antibiotics with the synthesis and evaluation of a series of 59 derivatives with variations in the C ring or C and D rings. A total of 17 compounds showed activity against S. aureus. Four derivatives were evaluated against a panel of 16 Gram-positive strains, inclusive of several methicillin-resistant S. aureus strains. These compounds are broadly active against Gram-positive bacteria.
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