ArticleOncotarget2015
Brain development is impaired in c-fos -/- mice.
Article in Oncotarget, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- The universal role of adaptive transcription in health and disease.The FEBS journal · 2025Review
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- Potential chemopreventive effects of Broccoli extract supplementation against 7, 12 dimethyl Benz(a)anthracene (DMBA) -induced toxicity in female rats.Scientific reports · 2023Article
- Disruption ofFrontiers in cell and developmental biology · 2023Article
- Magnetic activation of TREK1 triggers stress signalling and regulates neuronal branching in SH-SY5Y cells.Frontiers in medical technology · 2022Article
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- Impact of Reck expression and promoter activity in neuronal in vitro differentiation.Molecular biology reports · 2021Article
- The moonlighting protein c-Fos activates lipid synthesis in neurons, an activity that is critical for cellular differentiation and cortical development.The Journal of biological chemistry · 2020Article
- Lipid Metabolism in Neurons: A Brief Story of a Novel c-Fos-Dependent Mechanism for the Regulation of Their Synthesis.Frontiers in cellular neuroscience · 2019Review
- Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk.Nature genetics · 2018Article
- c-Fos downregulation positively regulates EphA5 expression in a congenital hypothyroidism rat model.Journal of molecular histology · 2018Article
- A sparse differential clustering algorithm for tracing cell type changes via single-cell RNA-sequencing data.Nucleic acids research · 2018Article
- Enhancer SINEs Link Pol III to Pol II Transcription in Neurons.Cell reports · 2017Article
- Transcriptome profiling of the subventricular zone and dentate gyrus in an animal model of Parkinson's disease.International journal of molecular medicine · 2017Article
- Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos.The Journal of experimental medicine · 2017Article
- Analyses of mRNA Profiling through RNA Sequencing on a SAMP8 Mouse Model in Response to Ginsenoside Rg1 and Rb1 Treatment.Frontiers in pharmacology · 2017Article
- AP1 transcription factors are required to maintain the peripheral taste system.Cell death & disease · 2016Article
- c-Fos importance for brain development.Aging · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
c-Fos is a proto-oncogene involved in diverse cellular functions. Its deregulation has been associated to abnormal development and oncogenic progression. c-fos-/- mice are viable but present a reduction in their body weight and brain size. We examined the importance of c-Fos during neocortex development at 13.5, 14.5 and 16.5 days of gestation. At E14.5, neocortex thickness, apoptosis, mitosis and expression of markers along the different stages of Neural Stem Progenitor Cells (NSPCs) differentiation in c-fos-/- and wild-type mice were analyzed. A ~15% reduction in the neocortex thickness of c-fos-/- embryos was observed which correlates with a decrease in the number of differentiated cells and an increase in apoptosis at the ventricular zone. No difference in mitosis rate was observed, although the mitotic angle was predominantly vertical in c-fos-/- embryos, suggesting a reduced trend of NSPCs to differentiate. At E13.5, changes in differentiation markers start to be apparent and are still clearly observed at E16.5. A tendency of more AP-1/DNA complexes present in nuclear extracts of cerebral cortex from c-fos-/- embryos with no differences in the lipid synthesis activity was found. These results suggest that c-Fos is involved in the normal development of NSPCs by means of its AP-1 activity.
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