ArticlePlant physiology2015
Histone H2B Monoubiquitination Mediated by HISTONE MONOUBIQUITINATION1 and HISTONE MONOUBIQUITINATION2 Is Involved in Anther Development by Regulating Tapetum Degradation-Related Genes in Rice.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 61 citations in OpenAlex.
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- Genome-wide identification ofFrontiers in plant science · 2026Article
- Phosphoproteomic Analysis Reveals Impairment of Rice Germination by Chloramphenicol.Plants (Basel, Switzerland) · 2025Article
- TheGenes · 2025Article
- Identification of the new allele ptc1-2 and analysis of the regulatory role of PTC1 gene in rice anther development.BMC plant biology · 2024Article
- Research Progress in the Regulation of the ABA Signaling Pathway by E3 Ubiquitin Ligases in Plants.International journal of molecular sciences · 2024Review
- A Systematic Investigation of Lipid Transfer Proteins Involved in Male Fertility and Other Biological Processes in Maize.International journal of molecular sciences · 2023Article
- Cytological Analysis and Fine Mapping of paa1 (Post-meiosis Abnormal Anther 1) Mutant with Abnormal Tapetum and Microspore Development.Biochemical genetics · 2022Article
- Whole-genome resequencing of the wheat A subgenome progenitor Triticum urartu provides insights into its demographic history and geographic adaptation.Plant communications · 2022Article
- Epigenetic Dynamics and Regulation of Plant Male Reproduction.International journal of molecular sciences · 2022Review
- (De)Activation (Ir)Reversibly or Degradation: Dynamics of Post-Translational Protein Modifications in Plants.Life (Basel, Switzerland) · 2022Review
- Genome-wide in silico analysis of long intergenic non-coding RNAs from rice peduncles at the heading stage.Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- Evolutionary and Characteristic Analysis of RING-DUF1117 E3 Ubiquitin Ligase Genes inBiomolecules · 2021Article
- A nuclear-targeted effector of Rhizophagus irregularis interferes with histone 2B mono-ubiquitination to promote arbuscular mycorrhisation.The New phytologist · 2021Article
- Exploiting Genic Male Sterility in Rice: From Molecular Dissection to Breeding Applications.Frontiers in plant science · 2021Review
- The chromatin-modifying protein HUB2 is involved in the regulation of lignin composition in xylem vessels.Journal of experimental botany · 2020Article
- Article
- Overexpression of GmUBC9 Gene Enhances Plant Drought Resistance and Affects Flowering TimeFrontiers in plant science · 2020Article
- H2Bub1 RegulatesPlant physiology · 2020Article
- Identification and Validation of a Novel Major Quantitative Trait Locus for Plant Height in Common Wheat (Frontiers in genetics · 2020Article
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histone H2B monoubiquitination (H2Bub1) is an important regulatory mechanism in eukaryotic gene transcription and is essential for normal plant development. However, the function of H2Bub1 in reproductive development remains elusive. Here, we report rice (Oryza sativa) HISTONE MONOUBIQUITINATION1 (OsHUB1) and OsHUB2, the homologs of Arabidopsis (Arabidopsis thaliana) HUB1 and HUB2 proteins, which function as E3 ligases in H2Bub1, are involved in late anther development in rice. oshub mutants exhibit abnormal tapetum development and aborted pollen in postmeiotic anthers. Knockout of OsHUB1 or OsHUB2 results in the loss of H2Bub1 and a reduction in the levels of dimethylated lysine-4 on histone 3 (H3K4me2). Anther transcriptome analysis revealed that several key tapetum degradation-related genes including OsC4, rice Cysteine Protease1 (OsCP1), and Undeveloped Tapetum1 (UDT1) were down-regulated in the mutants. Further, chromatin immunoprecipitation assays demonstrate that H2Bub1 directly targets OsC4, OsCP1, and UDT1 genes, and enrichment of H2Bub1 and H3K4me2 in the targets is consistent to some degree. Our studies suggest that histone H2B monoubiquitination, mediated by OsHUB1 and OsHUB2, is an important epigenetic modification that in concert with H3K4me2, modulates transcriptional regulation of anther development in rice.
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