ArticleGenes & nutrition2015
Identification of Mest/Peg1 gene expression as a predictive biomarker of adipose tissue expansion sensitive to dietary anti-obesity interventions.
Article in Genes & nutrition, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The trial behind it
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Trial
- Article
- Increased spontaneous physical activity in female MEST-deficient mice protects against diet-induced obesity.Frontiers in endocrinology · 2025Article
- Uncovering the Epigenetic Marks Involved in Mediating Salt Stress Tolerance in Plants.Frontiers in genetics · 2022Review
- Protective Effects of Individual and Combined Low Dose Beta-Carotene and Metformin Treatments against High-Fat Diet-Induced Responses in Mice.Nutrients · 2021Article
- Is Extra Virgin Olive Oil an Ally for Women's and Men's Cardiovascular Health?Cardiovascular therapeutics · 2020Review
- Article
- Antidiabetic Effects of Hydroxytyrosol: In Vitro and In Vivo Evidence.Antioxidants (Basel, Switzerland) · 2019Review
- A Lipophilic Fucoxanthin-RichNutrients · 2019Article
- Hydroxytyrosol Improves Obesity and Insulin Resistance by Modulating Gut Microbiota in High-Fat Diet-Induced Obese Mice.Frontiers in microbiology · 2019Article
- Deciphering the Anti-obesity Benefits of Resveratrol: The "Gut Microbiota-Adipose Tissue" Axis.Frontiers in endocrinology · 2019Review
- Mesoderm-specific transcript localization in the ER and ER-lipid droplet interface supports a role in adipocyte hypertrophy.Journal of cellular biochemistry · 2018Article
- DNA methylation of imprinted genes at birth is associated with child weight status at birth, 1 year, and 3 years.Clinical epigenetics · 2018Article
- C57BL/6J mice as a polygenic developmental model of diet-induced obesity.Physiological reports · 2017Article
- Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest).PloS one · 2017Article
- Beneficial effects of exercise on offspring obesity and insulin resistance are reduced by maternal high-fat diet.PloS one · 2017Article
- Anti-obesity effects of resveratrol: comparison between animal models and humans.Journal of physiology and biochemistry · 2016Review
- Molecular correlates of fat mass expansion in C57BL/6J mice after short-term exposure to dietary fat.Annals of the New York Academy of Sciences · 2016Article
- Whole Blood RNA as a Source of Transcript-Based Nutrition- and Metabolic Health-Related Biomarkers.PloS one · 2016Article
- Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity.Genes & nutrition · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Food components with anti-obesity properties are commonly evaluated using mouse models of diet-induced obesity. The ability of these components to reduce or prevent white adipose tissue (WAT) accumulation is usually tested in feeding trials of several weeks duration in order to detect significant effects on fat mass expansion. Here, we aimed to identify early, predictive biomarkers for WAT expansion. We performed a 5-day high-fat diet (HFD) feeding trial with C57BL/6J mice using different established anti-obesity interventions: epigallocatechin gallate, replacing dietary lipids by n-3 PUFA, and increasing dietary protein. WAT gene expression was analyzed of genes known to be similarly affected by short- and long-term HFD. Gene expression of Leptin and Mest (mesoderm-specific transcript) was increased by HFD and normalized by all anti-obesity interventions. In a second experiment, translatability to whole blood-based expression data was assessed. Mice were challenged for 21 days with a HFD without or with simultaneous treatment with anti-obesity bioactives, hydroxytyrosol or resveratrol, and compared for parameters including Leptin and Mest expression in whole blood at day 5. While Leptin mRNA could not be detected in mouse whole blood, there was an induction of Mest mRNA by HFD which was suppressed by hydroxytyrosol. Moreover, Mest expression in whole blood at day 5 positively correlated with adiposity and negatively with lean body mass and the subcutaneous/visceral fat ratio at day 21. We conclude that gene expression of Leptin and Mest in WAT and of Mest in whole blood represent early, predictive markers of adipose tissue expansion of potential usefulness in nutritional studies and trials.
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Registered trials
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