ArticleCurrent reviews in musculoskeletal medicine2015
Pathophysiology and risk factors for osteonecrosis.
Article in Current reviews in musculoskeletal medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 154 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
154 citing papers in PubMed, 8 syntheses or guidelines pooled it, 298 citations in OpenAlex.
- Meta-analysis of factors for osteonecrosis in systemic lupus erythematosus: integration of comprehensive literatures and multicenter databases.Frontiers in immunology · 2026Pooled it
- Conservative Treatment in Avascular Necrosis of the Femoral Head: A Systematic Review.Medical sciences (Basel, Switzerland) · 2024Pooled it
- Femoral head avascular necrosis in COVID-19 survivors: a systematic review.Rheumatology international · 2023Pooled it
- Does Diabetes Mellitus Increase the Risk of Avascular Osteonecrosis? A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- The Risk of Avascular Necrosis Following the Stabilization of Femoral Neck Fractures: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2022Pooled it
- Integrative analyses of genes related to femoral head osteonecrosis: an umbrella review of systematic reviews and meta-analyses of observational studies.Journal of orthopaedic surgery and research · 2022Pooled it
- Evidence-Supported HBO Therapy in Femoral Head Necrosis: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- What are the outcomes of core decompression without augmentation in patients with nontraumatic osteonecrosis of the femoral head?International orthopaedics · 2021Pooled it
- Previously unexplored etiology for femoral head necrosis: Metagenomics detects no pathogens in necrotic femoral head tissue.World journal of clinical cases · 2022Trial
- The concurrence of osteochondromatosis and bone infarction in a patient with anterior cruciate ligament rupture: a rare case report.International journal of surgery case reports · 2026Article
- Moth-Eaten Osteolysis of Multiple Foot Bones After a Conservatively Treated "Stable" Ankle Fracture: A Case Report and Literature Review.Clinical case reports · 2026Article
- Avascular necrosis of the femoral head following hysteroscopic myomectomy: Evaluation of bone perfusion using dynamic contrast-enhanced MRI and intravoxel incoherent motion.Skeletal radiology · 2026Article
- Evidence-Based Management and Functional Outcomes of Femoral Head Avascular Necrosis: A Systematic Review.Cureus · 2026Review
- Hypoparathyroidism and Avascular Necrosis of the Hip Joint: A Case Report.Clinical case reports · 2026Article
- Osteonecrosis Research in Orthopedics and Traumatology: A Global Bibliometric Analysis of Publication Trends, Key Contributors, and Thematic Evolution.Orthopaedic surgery · 2026Article
- When Chronic Pain Clouds Acute Diagnosis: Femoral Shaft Osteonecrosis With SuperimposedClinical case reports · 2026Article
- Efficacy and Risks of Intradiscal Electrothermal Therapy (IDET) for Treatment of Low Back Pain: A Narrative Review.Current pain and headache reports · 2026Review
- Risk factors for Kienböck's disease and need for surgical intervention: a nationwide register study from Finland.The Journal of hand surgery, European volume · 2026Article
- Concurrent histological lesions and molecular detection of porcine circovirus 3 in pigs with skeletal abnormalities and humpy-back posture.Veterinary pathology · 2026Article
- Vertebral body osteonecrosis: Evolving imaging features over time.Radiology case reports · 2026Article
94 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Osteonecrosis, also known as avascular necrosis or AVN, is characterized by a stereotypical pattern of cell death and a complex repair process of bone resorption and formation. It is not the necrosis itself but rather the resorptive component of the repair process that results in loss of structural integrity and subchondral fracture. Most likely, a common pathophysiological pathway exists involving compromised subchondral microcirculation. Decreased femoral head blood flow can occur through three mechanisms: vascular interruption by fractures or dislocation, intravascular occlusion from thrombi or embolic fat, or intraosseous extravascular compression from lipocyte hypertrophy or Gaucher cells. In this review, we emphasize etiologic relationships derived mostly from longitudinal cohort studies or meta-analyses whose causal relationships to osteonecrosis can be estimated with confidence. Understanding risk factors and pathophysiology has therapeutic implications since several treatment regimens are available to optimize femoral head circulation, interrupt bone resorption, and preserve the subchondral bone.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.