ArticleMedical & biological engineering & computing2016
Differential impact of local stiffening and narrowing on hemodynamics in repaired aortic coarctation: an FSI study.
Article in Medical & biological engineering & computing, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 30 citations in OpenAlex.
- Geometric Determinants of Post-stenotic Energetics in Coarctation of Aorta: Linking Centerline Morphology to Downstream Energy Loss.Annals of biomedical engineering · 2026Article
- Effect of Balloon-Dilated Restenosis on Exercise Performance and Cardiac Function in Children After Coarctation Repair.Pediatric cardiology · 2026Article
- Computational model of coarctation of the aorta in rabbits suggests persistent ascending aortic remodeling post-correction.Biomechanics and modeling in mechanobiology · 2025Article
- A systematic quantification of hemodynamic differences persisting after aortic coarctation repair.Frontiers in bioengineering and biotechnology · 2025Article
- Article
- Hypertension after coarctation repair-a systematic review.Translational pediatrics · 2022Review
- Recent Advances in Biomechanical Characterization of Thoracic Aortic Aneurysms.Frontiers in cardiovascular medicine · 2020Review
- Measurement, Analysis and Interpretation of Pressure/Flow Waves in Blood Vessels.Frontiers in physiology · 2020Review
- High-Frequency Fluctuations in Post-stenotic Patient Specific Carotid Stenosis Fluid Dynamics: A Computational Fluid Dynamics Strategy Study.Cardiovascular engineering and technology · 2019Article
- The aorta after coarctation repair - effects of calibre and curvature on arterial haemodynamics.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2019Article
- Reduced Aortic Distensibility is Associated With Higher Aorto-Carotid Wave Transmission and Central Aortic Systolic Pressure in Young Adults After Coarctation Repair.Journal of the American Heart Association · 2019Article
- Hemodynamic assessments of the ascending thoracic aortic aneurysm using fluid-structure interaction approach.Medical & biological engineering & computing · 2018Article
- A new model for the artificial aorta blood vessels using double-sided radial functionally graded biomaterials.Medical & biological engineering & computing · 2017Article
- Abnormal Wave Reflections and Left Ventricular Hypertrophy Late After Coarctation of the Aorta Repair.Hypertension (Dallas, Tex. : 1979) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
Even after successful treatment of aortic coarctation, a high risk of cardiovascular morbidity and mortality remains. Uncertainty exists on the factors contributing to this increased risk among which are the presence of (1) a residual narrowing leading to an additional resistance and (2) a less distensible zone disturbing the buffer function of the aorta. As the many interfering factors and adaptive physiological mechanisms present in vivo prohibit the study of the isolated impact of these individual factors, a numerical fluid-structure interaction model is developed to predict central hemodynamics in coarctation treatment. The overall impact of a stiffening on the hemodynamics is limited, with a small increase in systolic pressure (up to 8 mmHg) proximal to the stiffening which is amplified with increasing stiffening and length. A residual narrowing, on the other hand, affects the hemodynamics significantly. For a short segment (10 mm), the combination of a stiffening and narrowing (coarctation index 0.5) causes an increase in systolic pressure of 58 mmHg, with 31 mmHg due to narrowing and an additional 27 mmHg due to stiffening. For a longer segment (25 mm), an increase in systolic pressure of 50 mmHg is found, of which only 9 mmHg is due to stiffening.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.