ArticleEuropean journal of nuclear medicine and molecular imaging2015
Test-retest repeatability of myocardial blood flow and infarct size using ¹¹C-acetate micro-PET imaging in mice.
Article in European journal of nuclear medicine and molecular imaging, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Recent Advances in Cardiovascular Diseases Research Using Animal Models and PET Radioisotope Tracers.International journal of molecular sciences · 2022Review
- PET Imaging of Post-infarct Myocardial Inflammation.Current cardiology reports · 2021Review
- Cardiac 18F-FDG Positron Emission Tomography: An Accurate Tool to MonitorFrontiers in cardiovascular medicine · 2021Article
- Evaluation of cardiac function by nuclear imaging in preclinical studies.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Frontiers in positron emission tomography imaging of the vulnerable atherosclerotic plaque.Cardiovascular research · 2019Review
- Quantification of myocardial uptake rate constants in dynamic small-animal SPECT using a cardiac phantom.Physics in medicine and biology · 2019Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeGlobal and regional responses of absolute myocardial blood flow index (iMBF) are used as surrogate markers to assess response to therapies in coronary artery disease. In this study, we assessed the test-retest repeatability of iMBF imaging, and the accuracy of infarct sizing in mice using (11)C-acetate PET.
methods(11)C-Acetate cardiac PET images were acquired in healthy controls, endothelial nitric oxide synthase (eNOS) knockout transgenic mice, and mice after myocardial infarction (MI) to estimate global and regional iMBF, and myocardial infarct size compared to (18)F-FDG PET and ex-vivo histology results.
resultsGlobal test-retest iMBF values had good coefficients of repeatability (CR) in healthy mice, eNOS knockout mice and normally perfused regions in MI mice (CR = 1.6, 2.0 and 1.5 mL/min/g, respectively). Infarct size measured on (11)C-acetate iMBF images was also repeatable (CR = 17 %) and showed a good correlation with the infarct sizes found on (18)F-FDG PET and histopathology (r (2) > 0.77; p < 0.05).
conclusion(11)C-Acetate micro-PET assessment of iMBF and infarct size is repeatable and suitable for serial investigation of coronary artery disease progression and therapy.
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Registered trials
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