ReviewBiochimica et biophysica acta2016
Stressing out over long noncoding RNA.
Review in Biochimica et biophysica acta, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed.
- Targeting HSF1 for cancer treatment: mechanisms and inhibitor development.Theranostics · 2023Review
- Long Noncoding RNAs That Function in Nutrition: Lnc-ing Nutritional Cues to Metabolic Pathways.Annual review of nutrition · 2022Review
- LncRNAs and Chromatin Modifications Pattern mFrontiers in genetics · 2022Review
- Transcriptome-wide study revealed m6A regulation of embryonic muscle development in Dingan goose (Anser cygnoides orientalis).BMC genomics · 2021Article
- Genome-wide identification and functional prediction of long non-coding RNAs in Sprague-Dawley rats during heat stress.BMC genomics · 2021Article
- The long non-coding RNA HLNC1 potentiates hepatocellular carcinoma progression via interaction with USP49.Journal of clinical laboratory analysis · 2020Article
- Tidying-up the plant nuclear space: domains, functions, and dynamics.Journal of experimental botany · 2020Review
- Nucleolus-associated chromatin domains are maintained under heat stress, despite nucleolar reorganization in Arabidopsis thaliana.Journal of plant research · 2020Article
- Life time of some RNA products of rDNA intergenic spacer in HeLa cells.Histochemistry and cell biology · 2019Article
- Silencing an insulin-induced lncRNA, LncASIR, impairs the transcriptional response to insulin signalling in adipocytes.Scientific reports · 2019Article
- Nucleolar Sequestration: Remodeling Nucleoli Into Amyloid Bodies.Frontiers in genetics · 2019Article
- Non-coding RNAome of RPE cells under oxidative stress suggests unknown regulative aspects of Retinitis pigmentosa etiopathogenesis.Scientific reports · 2018Article
- Identification of long non-coding RNABioscience reports · 2018Article
- The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility.PLoS genetics · 2018Article
- Cytoplasmic functions of long noncoding RNAs.Wiley interdisciplinary reviews. RNA · 2018Review
- Molecular mechanisms of long noncoding RNAs and their role in disease pathogenesis.Oncotarget · 2018Review
- Radiation-Induced Long Noncoding RNAs in a Mouse Model after Whole-Body Irradiation.Radiation research · 2018Article
- Review
- Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress.Cell discovery · 2018Article
- Crosstalk between the Notch signaling pathway and non-coding RNAs in gastrointestinal cancers.Oncology letters · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Genomic studies have revealed that humans possess far fewer protein-encoding genes than originally predicted. These over-estimates were drawn from the inherent developmental and stimuli-responsive complexity found in humans and other mammals, when compared to lower eukaryotic organisms. This left a conceptual void in many cellular networks, as a new class of functional molecules was necessary for "fine-tuning" the basic proteomic machinery. Transcriptomics analyses have determined that the vast majority of the genetic material is transcribed as noncoding RNA, suggesting that these molecules could provide the functional diversity initially sought from proteins. Indeed, as discussed in this review, long noncoding RNAs (lncRNAs), the largest family of noncoding transcripts, have emerged as common regulators of many cellular stressors; including heat shock, metabolic deprivation and DNA damage. These stimuli, while divergent in nature, share some common stress-responsive pathways, notably inhibition of cell proliferation. This role intrinsically makes stress-responsive lncRNA regulators potential tumor suppressor or proto-oncogenic genes. As the list of functional RNA molecules continues to rapidly expand it is becoming increasingly clear that the significance and functionality of this family may someday rival that of proteins. This article is part of a Special Issue entitled: Clues to long noncoding RNA taxonomy1, edited by Dr. Tetsuro Hirose and Dr. Shinichi Nakagawa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.