Evidence map›Paper›PMID 26142451›Full record

ReviewTransactions of the Royal Society of Tropical Medicine and Hygiene2015

The global distribution of Crimean-Congo hemorrhagic fever.

Jane P Messina, David M Pigott, Nick Golding, Kirsten A Duda, John S Brownstein, Daniel J Weiss, Harry Gibson, Timothy P Robinson, Marius Gilbert, G R William Wint and 5 more

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Transactions of the Royal Society of Tropical Medicine and Hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 138 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
138citing papers in PubMed, 4 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

138 citing papers in PubMed, 4 syntheses or guidelines pooled it, 271 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Ribavirin for treating Crimean Congo haemorrhagic fever.The Cochrane database of systematic reviews · 2018
    Pooled it
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  17. Two autochthonous cases of Crimean-Congo haemorrhagic fever and the One Health response, Thessaly, Greece, 2025.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2025
    Article
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78 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Jane P MessinaDepartment of Zoology, University of Oxford, Oxford, UK jane.messina@zoo.ox.ac.uk.
David M PigottDepartment of Zoology, University of Oxford, Oxford, UK.
Nick GoldingWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Kirsten A DudaDepartment of Zoology, University of Oxford, Oxford, UK.
John S BrownsteinDepartment of Pediatrics, Harvard Medical School and Children's Hospital Informatics Program, Boston Children's Hospital, Boston, MA, USA.
Daniel J WeissDepartment of Zoology, University of Oxford, Oxford, UK.
Harry GibsonDepartment of Zoology, University of Oxford, Oxford, UK.
Timothy P RobinsonLivestock Systems and Environment (LSE), International Livestock Research Institute (ILRI),Nairobi, Kenya.
Marius GilbertBiological Control and Spatial Ecology, Université Libre de Bruxelles, Brussels, Belgium Fonds National de la Recherche Scientifique, Brussels, Belgium.
G R William WintDepartment of Zoology, University of Oxford, Oxford, UK.
Patricia A NuttallDepartment of Zoology, University of Oxford, Oxford, UK.
Peter W GethingDepartment of Zoology, University of Oxford, Oxford, UK.
Monica F MyersDepartment of Zoology, University of Oxford, Oxford, UK.
Dylan B GeorgeFogarty International Center, National Institutes of Health, Bethesda, MD, USA.
Simon I HayWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK Fogarty International Center, National Institutes of Health, Bethesda, MD, USA Institute for Health Metrics and Evaluation, University of Washington, Seattle, WA, USA.
University of Oxford · GBNational Institutes of Health · USBoston Children's Hospital · USCentre for Human Genetics · GBInternational Livestock Research Institute · KEUniversité Libre de Bruxelles · BE

Funding

A Platform for Modeling the Global Impact of Climate Change on Infectious DiseaseR01LM010812 · NLM · BOSTON CHILDREN'S HOSPITAL · PI BROWNSTEIN, JOHN S. · 2010 to 2015
$2.5M
NLM NIH HHS R01 LM010812Wellcome Trust 095066
6 · The paper itself

Abstract

backgroundCrimean-Congo hemorrhagic fever (CCHF) is a tick-borne infection caused by a virus (CCHFV) from the Bunyaviridae family. Domestic and wild vertebrates are asymptomatic reservoirs for the virus, putting animal handlers, slaughter-house workers and agricultural labourers at highest risk in endemic areas, with secondary transmission possible through contact with infected blood and other bodily fluids. Human infection is characterized by severe symptoms that often result in death. While it is known that CCHFV transmission is limited to Africa, Asia and Europe, definitive global extents and risk patterns within these limits have not been well described.

methodsWe used an exhaustive database of human CCHF occurrence records and a niche modeling framework to map the global distribution of risk for human CCHF occurrence.

resultsA greater proportion of shrub or grass land cover was the most important contributor to our model, which predicts highest levels of risk around the Black Sea, Turkey, and some parts of central Asia. Sub-Saharan Africa shows more focalized areas of risk throughout the Sahel and the Cape region.

conclusionsThese new risk maps provide a valuable starting point for understanding the zoonotic niche of CCHF, its extent and the risk it poses to humans.

Indexed as

Global HealthAbattoirsAnimal HusbandryAnimalsArachnid VectorsDisease OutbreaksFarmersGeographyHemorrhagic Fever, CrimeanHemorrhagic Fever Virus, Crimean-CongoHumansOccupational DiseasesOccupational ExposurePhylogenyTicksCrimean-Congo hemorrhagic feverCrimean-Congo hemorrhagic fever virusEcological niche modelingInfectious diseasesTick-borne diseasesVector-borne diseases

Identifiers

PMID26142451
PMCPMC4501401
OpenAlexW2158109789

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.