ArticleApplied microbiology and biotechnology2015
Differential modulation of avian β-defensin and Toll-like receptor expression in chickens infected with infectious bronchitis virus.
Article in Applied microbiology and biotechnology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 27 citations in OpenAlex.
- Dietary safflower seed oil supplementation modulates antiviral immunity in specific-pathogen-free chickens infected with fowl adenovirus serotype 8a.Poultry science · 2026Article
- Oral vitamin DPoultry science · 2026Article
- Clinical assessment and transcriptome analysis of host immune responses in a vaccination-challenge study using a glycoprotein G deletion mutant vaccine strain of infectious laryngotracheitis virus.Frontiers in immunology · 2024Article
- Pathogenicity and innate immune responses induced by fowl adenovirus serotype 8b in specific pathogen-free chicken.Poultry science · 2023Article
- Toll-Like Receptors Signaling Pathway of Quercetin Regulating Avian Beta-Defensin in the Ileum of Broilers.Frontiers in cell and developmental biology · 2022Article
- Immunization of Broiler Chickens With a Killed Chitosan NanoparticleFrontiers in physiology · 2022Article
- Innate immune responses of domestic pigeons to the infection of pigeon paramyxovirus type 1 virus.Poultry science · 2021Article
- Review
- Effects of avian infectious bronchitis with Newcastle disease and Marek's disease vaccinations on the expression of toll-like receptors and avian β-defensins in the kidneys of broiler chicks.Poultry science · 2020Article
- Peptidoglycan derived fromInnate immunity · 2020Article
- Infectious bronchitis virus inhibits activation of the TLR7 pathway, but not the TLR3 pathway.Archives of virology · 2020Article
- Effects of Toll-like Receptor Ligands on the Expression of Proinflammatory Cytokines and AvianThe journal of poultry science · 2020Article
- Article
- Comparative analysis of early immune responses induced by two strains of Newcastle disease virus in chickens.MicrobiologyOpen · 2019Article
- Transcripts of antibacterial peptides in chicken erythrocytes infected with Marek's disease virus.BMC veterinary research · 2018Article
- Changes in the Expression of AvianThe journal of poultry science · 2018Article
- Induction of Avian β-Defensin 2 Is Possibly Mediated by the p38 MAPK Signal Pathway in Chicken Embryo Fibroblasts After Newcastle Disease Virus Infection.Frontiers in microbiology · 2018Article
- Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks.Virologica Sinica · 2016Article
- Infection of Goose with Genotype VIId Newcastle Disease Virus of Goose Origin Elicits Strong Immune Responses at Early Stage.Frontiers in microbiology · 2016Article
- Host Avian Beta-Defensin and Toll-Like Receptor Responses of Pigeons following Infection with Pigeon Paramyxovirus Type 1.Applied and environmental microbiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The host innate immune response either clears invading viruses or allows the adaptive immune system to establish an effective antiviral response. In this study, both pathogenic (passage 3, P3) and attenuated (P110) infectious bronchitis virus (IBV) strains were used to study the immune responses of chicken to IBV infection. Expression of avian β-defensins (AvBDs) and Toll-like receptors (TLRs) in 16 tissues of chicken were compared at 7 days PI. The results showed that P3 infection upregulated the expression of AvBDs, including AvBD2, 4, 5, 6, 9, and 12, while P110 infection downregulated the expression of AvBDs, including AvBD3, 4, 5, 6, and 9 in most tissues. Meanwhile, the expression level of several TLRs showed a general trend of upregulation in the tissues of P3-infected chickens, while they were downregulated in the tissues of P110-infected chickens. The result suggested that compared with the P110 strain, the P3 strain induced a more pronounced host innate immune response. Furthermore, we observed that recombinant AvBDs (including 2, 6, and 12) demonstrated obvious anti-viral activity against IBV in vitro. Our findings contribute to the proposal that IBV infection induces an increase in the messenger RNA (mRNA) expression of some AvBDs and TLRs, which suggests that AvBDs may play significant roles in the resistance of chickens to IBV replication.
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