SynthesisAmerican journal of Alzheimer's disease and other dementias2016
From Subjective Cognitive Complaints to Dementia: Who is at Risk?: A Systematic Review.
Synthesis in American journal of Alzheimer's disease and other dementias, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04889560 (Home-based Cognitive Treatment of Early Stages of Cognitive Impairment in Neurodegenerative Diseases), which is not on this map. Cited by 134 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Home-based Cognitive Treatment of Early Stages of Cognitive Impairment in Neurodegenerative Diseases: Home CoRe
Who cites it
134 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- From Single-Modal to Multi-Modal Artificial Intelligence in Alzheimer's Disease: A Systematic Review of Databases, Modalities, Diagnostic Performance, and Clinical Translation Challenges.Sensors (Basel, Switzerland) · 2026Pooled it
- Association of Apathy With Risk of Incident Dementia: A Systematic Review and Meta-analysis.JAMA psychiatry · 2018Pooled it
- Pooled it
- Subjective Cognitive Complaints and Objective Cognitive Function in Aging: A Systematic Review and Meta-Analysis of Recent Cross-Sectional Findings.Neuropsychology review · 2016Pooled it
- Effects of repetitive transcranial magnetic stimulation on cognition through sleep slow-wave activity in older adults.Journal of neuroengineering and rehabilitation · 2026Trial
- Effects of multisession frontoparietal network anodal tDCS and cognitive rehabilitation on subjective cognitive impairment: a double-blind RCT.BMC neurology · 2026Trial
- Implementation and evaluation of a community-based mindful walking randomized controlled trial to sustain cognitive health in older African Americans at risk for dementia.BMC geriatrics · 2024Trial
- The Effects of Exergame Telerehabilitation in Persons With Subjective Cognitive Decline.The Gerontologist · 2024Trial
- Cognitive and immunological effects of yoga compared to memory training in older women at risk for alzheimer's disease.Translational psychiatry · 2024Trial
- Memory Strategy Training in Older Adults with Subjective Memory Complaints: A Randomized Controlled Trial.Journal of the International Neuropsychological Society : JINS · 2018Trial
- Linking epigenetic age acceleration to self-reported daily memory lapses: evidence from the National Study of Daily Experiences.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Age and sex differences in cognitive performance in people with subjective cognitive decline and associated worry: Findings from the Canadian Longitudinal Study on Aging.Journal of neuropsychology · 2026Article
- Observational
- Loneliness, Depression, and Subjective Memory Complaints in Middle-Aged and Older Adults: The Role of Meaning in Life.Psychiatry investigation · 2026Article
- Evaluating self- and informant-reported complaints as predictors of cognitive progression in subjective cognitive decline: A clinically-based evaluation.Journal of Alzheimer's disease : JAD · 2026Article
- Mood and Age Predict Cognitive Complaints in Memory Clinic Patients: A Machine-Learning and Linear Modeling Approach.European journal of neurology · 2026Article
- Young Adult Substance Use as a Predictor of Poor Self-Rated Memory Decades Later in Midlife.Journal of aging and health · 2026Article
- The Role of Dyads in Subjective Reporting and Prediction of Cognitive Worsening in Cognitively Unimpaired Individuals and Individuals with Subjective Cognitive Decline: Results of the CompAS Longitudinal Study.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Do Perspectives Matter? Comparing Patient, Informant, and Clinician Subjective Cognitive Decline.medRxiv : the preprint server for health sciences · 2026Article
- Factors associated with subjective cognitive complaints in former American football players.Journal of the International Neuropsychological Society : JINS · 2026Article
74 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Subjective cognitive complaints (SCCs) are frequent in the elderly population. The majority of individuals with subjective complaints never progress to significant cognitive decline, but some of them have a higher risk of progression to objective cognitive impairment than persons with no cognitive concerns. We performed a systematic review of community-based studies that focused on the progression risk associated with SCC and on the complainers’ characteristics associated with progression. Seventeen studies were included. As a group, SCCs are associated with a significantly higher risk of progression to dementia. Worried complainers, persons who refer an impact of their complaints on activities of daily living, and those whose complaints are also noticed by an informant have the highest risk of progression. Taking into account the fluctuating course of SCC and their frequent reversion, care should be taken to not overvaluate them. Further studies are necessary to better define risk features.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.