ArticleNeuroImage2015
Striatal and thalamic GABA level concentrations play differential roles for the modulation of response selection processes by proprioceptive information.
Article in NeuroImage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Minimum Alveolar Concentration-Awake of Sevoflurane is Decreased in Patients with Parkinson's Disease: An Up-and-Down Sequential Allocation Trial.Clinical interventions in aging · 2021Trial
- Influences of glutamine administration on response selection and sequence learning: a randomized-controlled trial.Scientific reports · 2017Trial
- GABAergic dysfunction in Parkinson's disease: insights from in vivo proton magnetic resonance spectroscopy.NPJ Parkinson's disease · 2026Article
- Article
- Unveiling MRI markers for Parkinson's Disease: GABAergic dysfunction and cortical changes.NeuroImage. Clinical · 2024Article
- Consequences of Disturbing Manganese Homeostasis.International journal of molecular sciences · 2023Review
- Chronic 3,4-Methylenedioxymethamphetamine (MDMA) Use Is Related to Glutamate and GABA Concentrations in the Striatum But Not the Anterior Cingulate Cortex.The international journal of neuropsychopharmacology · 2023Article
- Comparison of Half-Effective Concentration of Propofol in Patients with Parkinson's Disease and Non-Parkinson's Disease.Clinical interventions in aging · 2023Article
- Molecular Imaging of the GABAergic System in Parkinson's Disease and Atypical Parkinsonisms.Current neurology and neuroscience reports · 2022Review
- On the Role of Stimulus-Response Context in Inhibitory Control in Alcohol Use Disorder.Journal of clinical medicine · 2022Article
- Dopamine-induced changes to thalamic GABA concentration in impulsive Parkinson disease patients.NPJ Parkinson's disease · 2022Article
- Upper brainstem GABA levels in Parkinson's disease.Magma (New York, N.Y.) · 2021Article
- Anodal tDCS modulates specific processing codes during conflict monitoring associated with superior and middle frontal cortices.Brain structure & function · 2021Article
- GABA levels are differentially associated with bimanual motor performance in older as compared to young adults.NeuroImage · 2021Article
- Cognitive function: holarchy or holacracy?Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Review
- GABA and glutamate deficits from frontotemporal lobar degeneration are associated with disinhibition.Brain : a journal of neurology · 2020Article
- Applying deep learning to single-trial EEG data provides evidence for complementary theories on action control.Communications biology · 2020Article
- GABAergic changes in the thalamocortical circuit in Parkinson's disease.Human brain mapping · 2020Article
- Acute Alcohol Effects on Response Inhibition Depend on Response Automatization, but not on GABA or Glutamate Levels in the ACC and Striatum.Journal of clinical medicine · 2020Article
- Cervical Dystonia Is Associated With Aberrant Inhibitory Signaling Within the Thalamus.Frontiers in neurology · 2020Article
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Authors and funding
8 authors.
Funding
Abstract
The selection of appropriate responses is a complex endeavor requiring the integration of many different sources of information in fronto-striatal-thalamic circuits. An often neglected but relevant piece of information is provided by proprioceptive inputs about the current position of our limbs. This study examines the importance of striatal and thalamic GABA levels in these processes using GABA-edited magnetic resonance spectroscopy (GABA-MRS) and a Simon task featuring proprioception-induced interference in healthy subjects. As a possible model of deficits in the processing of proprioceptive information, we also included Parkinson's disease (PD) patients in this study. The results show that proprioceptive information about unusual postures complicates response selection processes in controls, but not in PD patients. The well-known deficits of PD patients in processing proprioceptive information can turn into a benefit when altered proprioceptive information would normally complicate response selection processes. Striatal and thalamic GABA levels play dissociable roles in the modulation of response selection processes by proprioceptive information: Striatal GABA levels seem to be important for the general speed of responding, most likely because striatal GABA promotes response selection. In contrast, the modulation of response conflict by proprioceptive information is closely related to thalamic GABA concentrations with higher concentration being related to a smaller response conflict effect. The most likely explanation for this finding is that the thalamus is involved in the integration of sensorimotor, attentional, and cognitive information for the purpose of response formation. Yet, this effect in the thalamus vanishes when controls and PD patients were analyzed separately.
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