Evidence map›Paper›PMID 26141928›Full record

ReviewPediatric nephrology (Berlin, Germany)2016

Autophagy in renal diseases.

Stéphanie De Rechter, Jean-Paul Decuypere, Ekaterina Ivanova, Lambertus P van den Heuvel, Humbert De Smedt, Elena Levtchenko, Djalila Mekahli

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in Pediatric nephrology (Berlin, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
5.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Autophagy: a double-edged sword in ischemia-reperfusion injury.Cellular & molecular biology letters · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Effects ofCurrent issues in molecular biology · 2023
    Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. Carboxymethylation ofOxidative medicine and cellular longevity · 2022
    Article
  16. Article
  17. Article
  18. Frontiers in pharmacology · 2021
    Article
  19. Article
  20. Crucial Roles of microRNA-Mediated Autophagy in Urologic Malignancies.International journal of biological sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Stéphanie De RechterDepartment of Paediatric Nephrology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium. stephanie.derechter@uzleuven.be.
Jean-Paul DecuypereLaboratory of Abdominal Transplantation, Department of Microbiology and Immunology Biomedical Sciences Group, KU Leuven, Leuven, Belgium.
Ekaterina IvanovaLaboratory of Paediatrics, KU Leuven, Leuven, Belgium.
Lambertus P van den HeuvelLaboratory of Paediatrics, KU Leuven, Leuven, Belgium.
Humbert De SmedtLaboratory of Molecular and Cellular Signalling, KU Leuven, Leuven, Belgium.
Elena LevtchenkoDepartment of Paediatric Nephrology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.
Djalila MekahliDepartment of Paediatric Nephrology, University Hospitals Leuven, Herestraat 49, 3000, Leuven, Belgium.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autophagy is the cell biology process in which cytoplasmic components are degraded in lysosomes to maintain cellular homeostasis and energy production. In the healthy kidney, autophagy plays an important role in the homeostasis and viability of renal cells such as podocytes and tubular epithelial cells and of immune cells. Recently, evidence is mounting that (dys)regulation of autophagy is implicated in the pathogenesis of various renal diseases, and might be an attractive target for new renoprotective therapies. In this review, we provide an overview of the role of autophagy in kidney physiology and kidney diseases.

Indexed as

AutophagyAnimalsEpithelial CellsHumansKidneyKidney DiseasesMolecular Targeted TherapySignal TransductionUrological AgentsUrological AgentsApoptosisAutophagyCystinosisDiabetic nephropathyFibrosisGlomerulosclerosisIschemia reperfusion injuryPolycystic kidney disease

Identifiers

PMID26141928
OpenAlexW1814069918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.