ArticleNeuroradiology2015
Combined MRI and MRS improves pre-therapeutic diagnoses of pediatric brain tumors over MRI alone.
Article in Neuroradiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Radiomics-driven neuro-fuzzy framework for rule generation to enhance explainability in MRI-based brain tumor segmentation.Frontiers in neuroinformatics · 2025Article
- Increased ketone levels as a key magnetic resonance spectroscopic findings during acute exacerbation inRadiology case reports · 2024Article
- In vivo magnetic resonance spectroscopy for the differential diagnosis of a cerebral mass in a boy with precocious puberty: a case report and review of the literature.Hormones (Athens, Greece) · 2023Review
- Proton MR Spectroscopy of Pediatric Brain Disorders.Diagnostics (Basel, Switzerland) · 2022Review
- Added value of magnetic resonance spectroscopy for diagnosing childhood cerebellar tumours.NMR in biomedicine · 2022Article
- Magnetic Resonance Imaging in the Contemporary Management of Medulloblastoma: Current and Emerging Applications.Methods in molecular biology (Clifton, N.J.) · 2022Review
- Translating state-of-the-art brain magnetic resonance imaging (MRI) techniques into clinical practice: multimodal MRI differentiates dementia subtypes in a traditional clinical setting.Quantitative imaging in medicine and surgery · 2021Article
- Diagnostic accuracy and added value of qualitative radiological review ofNeuro-oncology practice · 2019Article
- Prospective multicentre evaluation and refinement of an analysis tool for magnetic resonance spectroscopy of childhood cerebellar tumours.Pediatric radiology · 2018Article
- Evaluation of the added value ofNeuro-oncology practice · 2018Article
- The value of magnetic resonance spectroscopy as a supplement to MRI of the brain in a clinical setting.PloS one · 2018Article
- Magnetic Resonance Spectroscopy and Single-Photon Emission Computed Tomography in the Evaluation of Cerebral Tumors: A Case Report.Journal of clinical medicine research · 2017Article
- Advanced MR imaging in hemispheric low-grade gliomas before surgery; the indications and limits in the pediatric age.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2016Article
- The diagnostic accuracy of multiparametric MRI to determine pediatric brain tumor grades and types.Journal of neuro-oncology · 2016Article
- Advanced MRI for Pediatric Brain Tumors with Emphasis on Clinical Benefits.Korean journal of radiologyReview
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Authors and funding
7 authors.
Funding
Abstract
introductionThe specific goal of this study was to determine whether the inclusion of MRS had a measureable and positive impact on the accuracy of pre-surgical MR examinations of untreated pediatric brain tumors over that of MRI alone in clinical practice.
methodsFinal imaging reports of 120 pediatric patients with newly detected brain tumors who underwent combined MRI/MRS examinations were retrospectively reviewed. Final pathology was available in all cases. Group A comprised 60 subjects studied between June 2001 and January 2005, when MRS was considered exploratory and radiologists utilized only conventional MRI to arrive at a diagnosis. For group B, comprising 60 subjects studied between January 2005 and March 2008, the radiologists utilized information from both MRI and MRS. Furthermore, radiologists revisited group A (blind review, time lapse >4 years) to determine whether the additional information from MRS would have altered their interpretation.
resultsSixty-three percent of patients in group A were diagnosed correctly, whereas in 10% the report was partially correct with the final tumor type mentioned (but not mentioned as most likely tumor), while in 27% of cases the reports were wrong. For group B, the diagnoses were correct in 87%, partially correct in 5%, and incorrect in 8% of the cases, which is a significant improvement (p < 0.005). Re-review of combined MRI and MRS of group A resulted 87% correct, 7% partially correct, and 7% incorrect diagnoses, which is a significant improvement over the original diagnoses (p < 0.05).
conclusionAdding MRS to conventional MRI significantly improved diagnostic accuracy in preoperative pediatric patients with untreated brain tumors.
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