Evidence map›Paper›PMID 26141841›Full record

ArticleNeuroscience2015

Cognitive impairment and morphological changes in the dorsal hippocampus of very old female rats.

G R Morel, T Andersen, J Pardo, G O Zuccolilli, V L Cambiaggi, C B Hereñú, R G Goya

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 62 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

G R MorelINIBIOLP-Histology B-Pathology B, School of Medicine, National University of La Plata, La Plata city, Argentina.
T AndersenINIBIOLP-Histology B-Pathology B, School of Medicine, National University of La Plata, La Plata city, Argentina.
J PardoINIBIOLP-Histology B-Pathology B, School of Medicine, National University of La Plata, La Plata city, Argentina.
G O ZuccolilliInstitute of Anatomy, School of Veterinary Sciences, National University of La Plata, La Plata city, Argentina.
V L CambiaggiInstitute of Anatomy, School of Veterinary Sciences, National University of La Plata, La Plata city, Argentina.
C B HereñúINIBIOLP-Histology B-Pathology B, School of Medicine, National University of La Plata, La Plata city, Argentina.
R G GoyaINIBIOLP-Histology B-Pathology B, School of Medicine, National University of La Plata, La Plata city, Argentina. Electronic address: goya@isis.unlp.edu.ar.
Universidad Nacional de La Plata · ARBiochemistry Research Institute of La Plata · AR

Funding

Neuroprotective Gene Therapy in the Brain of Senile RatsR01AG029798 · NIA · NATIONAL UNIVERSITY OF LA PLATA · PI GOYA, RODOLFO G · 2008 to 2010
$471k
NCIRD CDC HHS U66 IP000597NIA NIH HHS R01 AG029798NIA NIH HHS R01AG029798
6 · The paper itself

Abstract

The hippocampus, a medial temporal lobe structure necessary for the formation of spatial memory, is particularly affected by both normal and pathologic aging. In previous studies, we observed a significant age-related increase in dopaminergic neuron loss in the hypothalamus and the substantia nigra of female rats, which becomes more conspicuous at extreme ages. Here, we extend our studies by assessing spatial memory in 4-6 month-old (young), 26-month-old (old) and 29-32-month-old (senile) Sprague-Dawley female rats as well as the age-related histopathological changes in their dorsal hippocampus. Age changes in spatial memory performance were assessed with a modified version of the Barnes maze test. We employed two probe trials (PTs), one and five days after training, respectively, in order to evaluate learning ability as well as short-term and longer-term spatial memory retention. A set of relevant hippocampal cell markers was also quantitated in the animals by means of an unbiased stereological approach. The results revealed that old rats perform better than senile rats in acquisition trials and young rats perform better than both aging groups. However, during short-term PT both aging groups showed a preserved spatial memory while in longer-term PT, spatial memory showed deterioration in both aged groups. Morphological analysis showed a marked decrease (94-97%) in doublecortin neuron number in the dentate gyrus in both aged groups and a reduction in glial fibrillary acidic protein-positive cell number in the stratum radiatum of aging rats. Astroglial process length and branching complexity decreased in aged rats. We conclude that while target-seeking activity and learning ability decrease in aged females, spatial memory only declines in the longer-term tests. The reduction in neuroblast number and astroglial arborescence complexity in the dorsal hippocampus are likely to play a role in the cognitive deficits of aging rats.

Indexed as

AgingAnimalsAstrocytesCognitionDoublecortin ProteinFemaleHippocampusNeuronsRatsRats, Sprague-DawleySpatial MemoryDoublecortin ProteinagingBarnes mazedoublecortinfemale-spatial memoryGFAPhippocampus

Identifiers

PMID26141841
PMCPMC4532610
OpenAlexW767528673

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.