Evidence map›Paper›PMID 26141573›Full record

ReviewCurrent allergy and asthma reports2015

Asthma is Different in Women.

Joe G Zein, Serpil C Erzurum

2 registry-linked trialsOpen access · greenAbstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 177 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
177citing papers in PubMed, 3 pooled it
9.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05623059 phase1 / phase2completednot on this mapstarted 2023, after this paper: background citation

Phase IIa Clinical Trial to Evaluate Pharmacokinetics and Safety of Slow Release DHEA

TypeinterventionalSponsorIndiana UniversityRan2023 to 2025Enrolled18ConditionsAsthma, GenotypeArmsSlow Release DHEA
NCT07179952 phase2not yet recruitingnot on this mapstarted 2027, after this paper: background citation

A Study to Evaluate Efficacy and Safety of Slow Release DHEA

TypeinterventionalSponsorIndiana UniversityRan2027 to 2028Enrolled30ConditionsAsthmaArmsSlow Release DHEA, Placebo
3 · Its place in the literature

Who cites it

177 citing papers in PubMed, 3 syntheses or guidelines pooled it, 340 citations in OpenAlex.

  1. Pooled it
  2. Sex Differences in Exercise-Induced Bronchoconstriction in Athletes: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2020
    Pooled it
  3. Pooled it
  4. Implementation of Coach McLungsBMC medical informatics and decision making · 2022
    Trial
  5. Trial
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Impact of the COVID-19 pandemic on adult asthma-related health care utilization.The journal of allergy and clinical immunology. Global · 2026
    Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026
    Review
  19. Review
  20. Article

117 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Joe G ZeinRespiratory Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio, 44195, USA, zeinj@ccf.org.
Serpil C Erzurum
Cleveland Clinic · US

Funding

Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2011 to 2020
$26.8M
Pulmonary Hypertension Breakthrough InitiativeR24HL123767 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ALDRED, MICHEALA A, ERZURUM, SERPIL C. · 2014 to 2017
$10.1M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
NHLBI NIH HHS P01 HL103453NHLBI NIH HHS R24 HL123767NHLBI NIH HHS U10 HL109250
6 · The paper itself

Abstract

Gender differences in asthma incidence, prevalence and severity have been reported worldwide. After puberty, asthma becomes more prevalent and severe in women, and is highest in women with early menarche or with multiple gestations, suggesting a role for sex hormones in asthma genesis. However, the impact of sex hormones on the pathophysiology of asthma is confounded by and difficult to differentiate from age, obesity, atopy, and other gender associated environmental exposures. There are also gender discrepancies in the perception of asthma symptoms. Understanding gender differences in asthma is important to provide effective education and personalized management plans for asthmatics across the lifecourse.

Indexed as

AnimalsAsthmaFemaleGonadal Steroid HormonesHumansMenopauseObesityPrevalenceSex CharacteristicsGonadal Steroid Hormones

Identifiers

PMID26141573
PMCPMC4572514
OpenAlexW817098076

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.