ArticleEuropean journal of nutrition2016
Low vitamin D status is associated with more depressive symptoms in Dutch older adults.
Article in European journal of nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 48 citations in OpenAlex.
- Dose ranging effects of vitamin D3 on the geriatric depression score: A clinical trial.The Journal of steroid biochemistry and molecular biology · 2018Trial
- The Association Between Serum Vitamin D and Lipid Levels in Patients With Depression: A Cross-Sectional Study.Alpha psychiatry · 2026Article
- Adherence to a healthy Nordic diet is associated with a lower prevalence of depressive symptoms.The British journal of nutrition · 2025Article
- Association of serum 25-hydroxyvitamin D with the risk of depression in individuals with prediabetes and diabetes: A prospective cohort study.The journal of nutrition, health & aging · 2025Article
- The Role of Vitamin D in the Management of Major Depressive Disorder: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Associations of vitamin D-related single nucleotide polymorphisms with post-stroke depression among ischemic stroke population.Frontiers in psychiatry · 2023Article
- Impaired spatial memory in adult vitamin D deficient BALB/c mice is associated with reductions in spine density, nitric oxide, and neural nitric oxide synthase in the hippocampus.AIMS neuroscience · 2022Article
- Nutrition and mental health: A review of current knowledge about the impact of diet on mental health.Frontiers in nutrition · 2022Review
- Serum Vitamin D and Depressive Symptomatology among Boston-Area Puerto Ricans.The Journal of nutrition · 2020Article
- Lower serum 25-hydroxycholecalciferol is associated with depressive symptoms in older adults in Southern Brazil.Nutrition journal · 2020Article
- Is there an association between serum 25(OH)DHormones (Athens, Greece) · 2020Article
- Review
- Effects of cholecalciferol on behavior and production of reactive oxygen species in female mice subjected to corticosterone-induced model of depression.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Vitamin D and Depression in Women: A Mini-review.Current neuropharmacology · 2020Review
- Vitamin D deficiency is associated with reduced hippocampal volume and disrupted structural connectivity in patients with mild cognitive impairment.Human brain mapping · 2019Article
- Impact of seasons on stroke-related depression, mediated by vitamin D status.BMC psychiatry · 2018Article
- Postnatal Vitamin D Intake Modulates Hippocampal Learning and Memory in Adult Mice.Frontiers in neuroscience · 2018Article
- Association between Obesity and Serum 25(OH)D Concentrations in Older Mexican Adults.Nutrients · 2017Article
Corrections and comments
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe existence of vitamin D receptors in the brain points to a possible role of vitamin D in brain function. We examined the association of vitamin D status and vitamin D-related genetic make-up with depressive symptoms amongst 2839 Dutch older adults aged ≥65 years.
methods25-Hydroxyvitamin D (25(OH)D) was measured, and five 'vitamin D-related genes' were selected. Depressive symptoms were measured with the 15-point Geriatric Depression Scale. Results were expressed as the relative risk of the score of depressive symptoms by quartiles of 25(OH)D concentration or number of affected alleles, using the lowest quartile or minor allele group as reference.
resultsA clear cross-sectional and prospective association between serum 25(OH)D and depressive symptom score was observed. Fully adjusted models indicated a 22 % (RR 0.78, 95 % CI 0.68-0.89), 21 % (RR 0.79, 95 % CI 0.68-0.90), and 18 % (RR 0.82, 95 % CI 0.71-0.95) lower score of depressive symptoms in people in the second, third, and fourth 25(OH)D quartiles, when compared to people in the first quartile (P for trend <0.0001). After 2 years of daily 15 µg vitamin D supplementation, similar associations were observed. 25(OH)D concentrations did not significantly interact with the selected genes.
conclusionLow serum 25(OH)D was associated with higher depressive symptom scores. No interactions between 25(OH)D concentrations and vitamin D genetic make-up were observed. In view of the probability of reverse causation, we propose that the association should be further examined in prospective studies as well as in randomized controlled trials.
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