Evidence map›Paper›PMID 26141078›Full record

ArticleBMC biology2015

Mechanotransduction: use the force(s).

Ewa K Paluch, Celeste M Nelson, Nicolas Biais, Ben Fabry, Jens Moeller, Beth L Pruitt, Carina Wollnik, Galina Kudryasheva, Florian Rehfeldt, Walter Federle

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed.

  1. Review
  2. Review
  3. RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
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  8. Biological Reinforced Concrete for Cartilage Repair With 3D Printing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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  12. Article
  13. Review
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  15. Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. Article

52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ewa K PaluchMRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK. e.paluch@ucl.ac.uk.
Celeste M NelsonChemical & Biological Engineering, Princeton University, 303 Hoyt Laboratory, William Street, Princeton, NJ, 08544, USA.
Nicolas BiaisBiology Department, Brooklyn College and the Graduate Center of the City University of New York, 2900 Bedford avenue, Brooklyn, NY, 11210, USA.
Ben FabryDepartment of Physics, University of Erlangen-Nuremberg, Henkestrasse 91, 91052, Erlangen, Germany.
Jens MoellerDepartment of Mechanical Engineering, Microsystems Laboratory, Stanford University, 496 Lomita Mall, Durand Building Rm 102, Stanford, CA, 94305, USA.
Beth L PruittDepartment of Mechanical Engineering and Molecular and Cellular Physiology, Microsystems Laboratory, Stanford University, by courtesy, 496 Lomita Mall, Durand Building Rm 213, Stanford, CA, 94305, USA.
Carina WollnikGeorg-August-University, 3rd Institute of Physics - Biophysics, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany.
Galina KudryashevaGeorg-August-University, 3rd Institute of Physics - Biophysics, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany.
Florian RehfeldtGeorg-August-University, 3rd Institute of Physics - Biophysics, Friedrich-Hund-Platz 1, 37077, Göttingen, Germany.
Walter FederleDepartment of Zoology, University of Cambridge, Downing Street, Cambridge, CB2 3EJ, UK.

Funding

Force Clamp Systems for Evaluation of MechanotransductionR01EB006745 · NIBIB · STANFORD UNIVERSITY · PI GOODMAN, MIRIAM B, PRUITT, BETH L · 2007 to 2014
$3.1M
Type IV pilus as a switch that determines consequences of Neisseria colonizationR01AI107966 · NIAID · UNIVERSITY OF ARIZONA · PI SO, MAGDALENE Y · 2013 to 2017
$2.3M
Mechanical Regulation of Mesenchyme and Mammalian Lung DevelopmentR01HL120142 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2014 to 2017
$1.6M
Spatial patterning of branching morphogenesisR01GM083997 · NIGMS · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2008 to 2012
$1.4M
Mechanobiology of Neisseria MicrocoloniesSC2AI116566 · NIAID · BROOKLYN COLLEGE · PI BIAIS, NICOLAS · 2014 to 2016
$471k
Mechanical regulation of branching morphogenesisR21HL110335 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2011 to 2012
$443k
Exogenous Fluid Forces and Branching of the Mammalian LungR21HL118532 · NHLBI · PRINCETON UNIVERSITY · PI NELSON, CELESTE M · 2014 to 2015
$442k
Biotechnology and Biological Sciences Research Council BB/E004156/1Medical Research Council MC_UU_12018/5NHLBI NIH HHS R01 HL120142NHLBI NIH HHS R21 HL110335NHLBI NIH HHS R21 HL118532NIAID NIH HHS R01 AI107966NIAID NIH HHS SC2 AI116566NIBIB NIH HHS 2R01EB006745-05NIBIB NIH HHS R01 EB006745NIGMS NIH HHS R01 GM083997
6 · The paper itself

Abstract

Mechanotransduction - how cells sense physical forces and translate them into biochemical and biological responses - is a vibrant and rapidly-progressing field, and is important for a broad range of biological phenomena. This forum explores the role of mechanotransduction in a variety of cellular activities and highlights intriguing questions that deserve further attention.

Indexed as

Mechanotransduction, CellularActomyosinAnimalsBiomechanical PhenomenaCell AdhesionFocal AdhesionsHumansKineticsLocomotionMesenchymal Stem CellsStress FibersActomyosin

Identifiers

PMID26141078
PMCPMC4491211

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.